psoriasis: An autoimmune condition characterized by red, well-delineated plaques with silvery scales that are usually on the extensor surfaces and scalp. They can occasionally present with these manifestations: pustules; erythema and scaling in intertriginous areas, and erythroderma, that are often distributed on extensor surfaces and scalp.
Endpoint definition
↥
Endpoint definition steps |
FinnGen |
|---|---|
Phenotype data |
473681 |
1. Apply sex-specific ruleNone |
473681 |
2. Check conditionsNone |
473681 |
3. Check pre-conditions, main-only, mode, registry filtersRegistry filters: 2 out of 7 registries used, show all original rules. |
466 |
4. Check minimum number of eventsNone |
466 |
5. Include endpointsNone |
466 |
6. Filter based on genotype QC (FinnGen only) |
447 |
Control definitions (FinnGen only)
Control exclude
L12_PAPULOSQUAMOUS
Extra metadata
Level in the ICD hierarchy
4
First used in FinnGen datafreeze
DF2
Parent code in ICD-10
L40
Name in latin
Psoriasis guttata
Similar endpoints
↥List of similar endpoints to
Guttate psoriasis
based on the number of shared cases.
Similar with more cases:
- Psoriasis
- Papulosquamous disorders
- Autoimmune diseases related-to ILD
- Autoimmune diseases
- Used for control exclusion in common control thyroid runs
Similar with less cases:
None
Case counts by codes
↥
Summary Statistics
↥-FinRegistry-
Key figures
| All | Female | Male | |
|---|---|---|---|
| Number of individuals | |||
| Whole population | 3699 | 2116 | 1568 |
| Only index persons | 3553 | 2064 | 1489 |
| Unadjusted period prevalence (%) | |||
| Whole population | 0.05 | 0.06 | 0.04 |
| Only index persons | 0.07 | 0.08 | 0.06 |
| Median age at first event (years) | |||
| Whole population | 41.77 | 41.62 | 41.86 |
| Only index persons | 41.40 | 41.48 | 41.29 |
-FinnGen-
Key figures
| All | Female | Male | |
|---|---|---|---|
| Number of individuals | 447 | 282 | 165 |
| Unadjusted period prevalence (%) | 0.10 | 0.11 | 0.08 |
| Median age at first event (years) | 47.22 | 45.21 | 50.65 |
-FinRegistry-
Age distribution of first events
-FinnGen-
Age distribution of first events
-FinRegistry-
Year distribution of first events
-FinnGen-
Year distribution of first events
-FinRegistry-
Cumulative Incidence Function
-FinnGen-
Cumulative Incidence Function
No data
Mortality – FinRegistry
↥Association
Association between endpoint L12_PSORI_GUTTATE and mortality.
Females
| Parameter | HR [95% CI] | p-value |
|---|---|---|
| L12_PSORI_GUTTATE | 1.255 [1.02, 1.54] | 0.032 |
| Birth year | 0.994 [0.99, 1.0] | 0.2 |
During the follow-up period (1.1.1998 — 31.12.2019), 164 out of 1925 females with L12_PSORI_GUTTATE died.
Males
| Parameter | HR [95% CI] | p-value |
|---|---|---|
| L12_PSORI_GUTTATE | 1.695 [1.38, 2.08] | < 0.001 |
| Birth year | 0.986 [0.98, 1.0] | 0.01 |
During the follow-up period (1.1.1998 — 31.12.2019), 209 out of 1420 males with L12_PSORI_GUTTATE died.
Mortality risk
Mortality risk for people of age
years, who have L12_PSORI_GUTTATE.| N-year risk | Females | Males |
|---|---|---|
| 1 | 0.107% | 0.352% |
| 5 | 0.745% | 1.989% |
| 10 | 1.799% | 4.954% |
| 15 | 3.345% | 9.073% |
| 20 | 5.875% | 14.936% |
Relationships between endpoints
↥Index endpoint: L12_PSORI_GUTTATE – Guttate psoriasis
GWS hits: -
Endpoint
Case Overlap
Survival Analysis
Genetic Correlations
Genetic Signals
N (Jaccard index)
HR [CI]
Extremity
rg [CI]
Extremity
Hits
Coloc Hits
FinRegistry
FinnGen
FinRegistry
FinnGen
FinnGen
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