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Pustulosis palmaris et plantaris

DOID EFO Endpoint Browser PheWeb

L12_PSORI_PUSTUPALM

Endpoint definition

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Endpoint definition steps

FinnGen

Phenotype data

473681

1. Apply sex-specific rule

None

473681

2. Check conditions

None

473681

3. Check pre-conditions, main-only, mode, registry filters

Registry filters:

  • Hospital discharge: ICD-10 — L40.3
  • Hospital discharge: ICD-9 — 6961D
  • Hospital discharge: ICD-8 — 68693
  • Cause of death: ICD-10 — L40.3
  • Cause of death: ICD-9 — 6961D
  • Cause of death: ICD-8 — 68693

2 out of 7 registries used, show all original rules.

1444

4. Check minimum number of events

None

1444

5. Include endpoints

None

1444

6. Filter based on genotype QC (FinnGen only)

1386

Control definitions (FinnGen only)

Control exclude L12_PAPULOSQUAMOUS

Extra metadata

Level in the ICD hierarchy 4
First used in FinnGen datafreeze DF2
Parent code in ICD-10 L40
Name in latin Pustulosis palmaris et plantaris

Case counts by codes

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FinnGen case counts by registry codes:

generic upset plot

Upset plot

Full data table

Summary Statistics

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-FinRegistry-

Key figures

All Female Male
Number of individuals
Whole population 9805 6825 2953
Only index persons 9263 6578 2685
Unadjusted period prevalence (%)
Whole population 0.16 0.20 0.08
Only index persons 0.20 0.24 0.10
Median age at first event (years)
Whole population 51.84 53.06 49.05
Only index persons 51.55 52.89 48.26

-FinnGen-

Key figures

All Female Male
Number of individuals 1386 994 392
Unadjusted period prevalence (%) 0.34 0.39 0.20
Median age at first event (years) 53.23 53.23 53.25

-FinRegistry-

Age distribution of first events

-FinnGen-

Age distribution of first events

-FinRegistry-

Year distribution of first events

-FinnGen-

Year distribution of first events

-FinRegistry-

Cumulative Incidence Function

-FinnGen-

Cumulative Incidence Function

Mortality – FinRegistry

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Association

Association between endpoint L12_PSORI_PUSTUPALM and mortality.

Females

Parameter HR [95% CI] p-value
L12_PSORI_PUSTUPALM 1.24 [1.1, 1.4] < 0.001
Birth year 0.998 [0.99, 1.01] 0.688

During the follow-up period (1.1.1998 — 31.12.2019), 556 out of 5683 females with L12_PSORI_PUSTUPALM died.

Males

Parameter HR [95% CI] p-value
L12_PSORI_PUSTUPALM 1.432 [1.25, 1.64] < 0.001
Birth year 0.988 [0.98, 1.0] 0.009

During the follow-up period (1.1.1998 — 31.12.2019), 387 out of 2303 males with L12_PSORI_PUSTUPALM died.

Mortality risk

Mortality risk for people of age

years, who have L12_PSORI_PUSTUPALM.

N-year risk Females Males
1 0.121% 0.28%
5 0.713% 1.631%
10 1.761% 4.463%
15 3.768% 8.079%
20 7.043% 14.014%

Relationships between endpoints

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Index endpoint: L12_PSORI_PUSTUPALM – Pustulosis palmaris et plantaris

GWS hits: -

Endpoint
Case Overlap
Survival Analysis
Genetic Correlations
Genetic Signals
N (Jaccard index)
HR [CI]
Extremity
rg [CI]
Extremity
Hits
Coloc Hits
FinRegistry
FinnGen
FinRegistry
FinnGen
FinnGen
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