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Acrodermatitis continua

DOID EFO Endpoint Browser PheWeb

L12_PSORI_ACRODERM

psoriasis: An autoimmune condition characterized by red, well-delineated plaques with silvery scales that are usually on the extensor surfaces and scalp. They can occasionally present with these manifestations: pustules; erythema and scaling in intertriginous areas, and erythroderma, that are often distributed on extensor surfaces and scalp.

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Endpoint definition

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Endpoint definition steps

FinnGen

Phenotype data

473681

1. Apply sex-specific rule

None

473681

2. Check conditions

None

473681

3. Check pre-conditions, main-only, mode, registry filters

Registry filters:

  • Hospital discharge: ICD-10 — L40.2
  • Hospital discharge: ICD-9 — 6961C
  • Hospital discharge: ICD-8 — 68696
  • Cause of death: ICD-10 — L40.2
  • Cause of death: ICD-9 — 6961C
  • Cause of death: ICD-8 — 68696

2 out of 7 registries used, show all original rules.

65

4. Check minimum number of events

None

65

5. Include endpoints

None

65

6. Filter based on genotype QC (FinnGen only)

63

Control definitions (FinnGen only)

Control exclude L12_PAPULOSQUAMOUS

Extra metadata

Level in the ICD hierarchy 4
First used in FinnGen datafreeze DF2
Parent code in ICD-10 L40
Name in latin Acrodermatitis continua (Hallopeau)

Case counts by codes

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FinnGen case counts by registry codes:

generic upset plot

Upset plot

Full data table

Summary Statistics

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-FinRegistry-

Key figures

All Female Male
Number of individuals
Whole population 449 266 181
Only index persons 419 250 169
Unadjusted period prevalence (%)
Whole population 0.01 0.01 0.01
Only index persons 0.01 0.01 0.01
Median age at first event (years)
Whole population 55.60 54.91 56.85
Only index persons 55.27 54.78 55.99

-FinnGen-

Key figures

All Female Male
Number of individuals 63 40 23
Unadjusted period prevalence (%) 0.01 0.02 0.01
Median age at first event (years) 54.53 51.82 59.25

-FinRegistry-

Age distribution of first events

-FinnGen-

Age distribution of first events

-FinRegistry-

Year distribution of first events

-FinnGen-

Year distribution of first events

-FinRegistry-

Cumulative Incidence Function

No data

-FinnGen-

Cumulative Incidence Function

No data

Mortality – FinRegistry

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Association

Association between endpoint L12_PSORI_ACRODERM and mortality.

Females

No data

Males

No data

Mortality risk

Mortality risk for people of age

years, who have L12_PSORI_ACRODERM.

N-year risk Females Males
1 No data No data
5 No data No data
10 No data No data
15 No data No data
20 No data No data

Relationships between endpoints

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Index endpoint: L12_PSORI_ACRODERM – Acrodermatitis continua

GWS hits: -

Endpoint
Case Overlap
Survival Analysis
Genetic Correlations
Genetic Signals
N (Jaccard index)
HR [CI]
Extremity
rg [CI]
Extremity
Hits
Coloc Hits
FinRegistry
FinnGen
FinRegistry
FinnGen
FinnGen
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