Tuberculosis, Cutaneous: Tuberculosis of the skin. It includes scrofuloderma and tuberculid, but not LUPUS VULGARIS.
Endpoint definition
↥
Endpoint definition steps |
FinnGen |
|---|---|
Phenotype data |
473681 |
1. Apply sex-specific ruleNone |
473681 |
2. Check conditionsNone |
473681 |
3. Check pre-conditions, main-only, mode, registry filtersRegistry filters: 2 out of 7 registries used, show all original rules. |
23982 |
4. Check minimum number of eventsNone |
23982 |
5. Include endpoints |
27810 |
6. Filter based on genotype QC (FinnGen only) |
26746 |
Control definitions (FinnGen only)
Controls for this endpoint are individuals that are not cases.
Extra metadata
Level in the ICD hierarchy
2
First used in FinnGen datafreeze
DF2
Infections of the skin and subcutaneous tissue
based on the number of shared cases.
Similar with more cases:
Similar with less cases:
Summary Statistics
↥-FinRegistry-
Key figures
| All | Female | Male | |
|---|---|---|---|
| Number of individuals | |||
| Whole population | 292113 | 122997 | 167237 |
| Only index persons | 252737 | 107278 | 145459 |
| Unadjusted period prevalence (%) | |||
| Whole population | 4.17 | 3.52 | 4.67 |
| Only index persons | 4.87 | 3.94 | 5.55 |
| Median age at first event (years) | |||
| Whole population | 35.06 | 37.42 | 33.21 |
| Only index persons | 35.44 | 38.11 | 33.48 |
-FinnGen-
Key figures
| All | Female | Male | |
|---|---|---|---|
| Number of individuals | 26746 | 13135 | 13611 |
| Unadjusted period prevalence (%) | 6.01 | 5.16 | 6.84 |
| Median age at first event (years) | 45.89 | 43.81 | 47.90 |
-FinRegistry-
Age distribution of first events
-FinnGen-
Age distribution of first events
-FinRegistry-
Year distribution of first events
-FinnGen-
Year distribution of first events
-FinRegistry-
Cumulative Incidence Function
-FinnGen-
Cumulative Incidence Function
Mortality – FinRegistry
↥Association
Association between endpoint L12_INFECT_SKIN and mortality.
Females
| Parameter | HR [95% CI] | p-value |
|---|---|---|
| L12_INFECT_SKIN | 2.273 [2.03, 2.55] | < 0.001 |
| Birth year | 0.99 [0.98, 1.0] | 0.015 |
During the follow-up period (1.1.1998 — 31.12.2019), 12647 out of 86781 females with L12_INFECT_SKIN died.
Males
| Parameter | HR [95% CI] | p-value |
|---|---|---|
| L12_INFECT_SKIN | 2.255 [2.02, 2.51] | < 0.001 |
| Birth year | 0.988 [0.98, 1.0] | 0.013 |
During the follow-up period (1.1.1998 — 31.12.2019), 17277 out of 114111 males with L12_INFECT_SKIN died.
Mortality risk
Mortality risk for people of age
years, who have L12_INFECT_SKIN.| N-year risk | Females | Males |
|---|---|---|
| 1 | 0.224% | 0.409% |
| 5 | 1.031% | 2.457% |
| 10 | 2.714% | 6.649% |
| 15 | 5.093% | 12.036% |
| 20 | 9.201% | 19.505% |
Relationships between endpoints
↥Index endpoint: L12_INFECT_SKIN – Infections of the skin and subcutaneous tissue
GWS hits: -
Endpoint
Case Overlap
Survival Analysis
Genetic Correlations
Genetic Signals
N (Jaccard index)
HR [CI]
Extremity
rg [CI]
Extremity
Hits
Coloc Hits
FinRegistry
FinnGen
FinRegistry
FinnGen
FinnGen
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