impetigo: A pyoderma consisting of three forms of skin lesions having either a thick, adherent, recurrent, dirty yellow crust with an erythematous margin (common or superficial impetigo) or lessions which are superficial, thin-walled, and bullous as found in bullous impetigo. The lesions in bullous (staphylococcal) impetigo, which are always caused by S aureus, are superficial, thin-walled, and bullous.
Endpoint definition
↥
Endpoint definition steps |
FinnGen |
|---|---|
Phenotype data |
473681 |
1. Apply sex-specific ruleNone |
473681 |
2. Check conditionsNone |
473681 |
3. Check pre-conditions, main-only, mode, registry filtersRegistry filters:
2 out of 7 registries used, show all original rules. |
1601 |
4. Check minimum number of eventsNone |
1601 |
5. Include endpointsNone |
1601 |
6. Filter based on genotype QC (FinnGen only) |
1541 |
Control definitions (FinnGen only)
Control exclude
L12_INFECT_SKIN
Extra metadata
Level in the ICD hierarchy
3
First used in FinnGen datafreeze
DF2
Parent code in ICD-10
L00-L08
Name in latin
Impetigo
Similar endpoints
↥List of similar endpoints to
Impetigo
based on the number of shared cases.
Similar with more cases:
- Infections of the skin and subcutaneous tissue
- Diseases of the skin and subcutaneous tissue
- Any event in hilmo or specialist outpatient
Similar with less cases:
None
Case counts by codes
↥
Summary Statistics
↥-FinRegistry-
Key figures
| All | Female | Male | |
|---|---|---|---|
| Number of individuals | |||
| Whole population | 28301 | 13366 | 14843 |
| Only index persons | 20231 | 9754 | 10477 |
| Unadjusted period prevalence (%) | |||
| Whole population | 0.40 | 0.38 | 0.41 |
| Only index persons | 0.38 | 0.36 | 0.40 |
| Median age at first event (years) | |||
| Whole population | 10.66 | 11.12 | 10.05 |
| Only index persons | 15.69 | 15.96 | 15.43 |
-FinnGen-
Key figures
| All | Female | Male | |
|---|---|---|---|
| Number of individuals | 1541 | 885 | 656 |
| Unadjusted period prevalence (%) | 0.34 | 0.35 | 0.33 |
| Median age at first event (years) | 23.11 | 23.94 | 21.99 |
-FinRegistry-
Age distribution of first events
-FinnGen-
Age distribution of first events
-FinRegistry-
Year distribution of first events
-FinnGen-
Year distribution of first events
-FinRegistry-
Cumulative Incidence Function
-FinnGen-
Cumulative Incidence Function
Mortality – FinRegistry
↥Association
Association between endpoint L12_IMPETIGO and mortality.
Females
| Parameter | HR [95% CI] | p-value |
|---|---|---|
| L12_IMPETIGO | 2.412 [1.88, 3.09] | < 0.001 |
| Birth year | 0.995 [0.98, 1.0] | 0.296 |
During the follow-up period (1.1.1998 — 31.12.2019), 434 out of 8762 females with L12_IMPETIGO died.
Males
| Parameter | HR [95% CI] | p-value |
|---|---|---|
| L12_IMPETIGO | 2.621 [2.05, 3.35] | < 0.001 |
| Birth year | 0.991 [0.98, 1.0] | 0.068 |
During the follow-up period (1.1.1998 — 31.12.2019), 538 out of 9066 males with L12_IMPETIGO died.
Mortality risk
Mortality risk for people of age
years, who have L12_IMPETIGO.| N-year risk | Females | Males |
|---|---|---|
| 1 | 0.191% | 0.601% |
| 5 | 1.282% | 3.415% |
| 10 | 3.315% | 8.425% |
| 15 | 6.262% | 15.572% |
| 20 | 11.018% | 26.219% |
Relationships between endpoints
↥Index endpoint: L12_IMPETIGO – Impetigo
GWS hits: -
Endpoint
Case Overlap
Survival Analysis
Genetic Correlations
Genetic Signals
N (Jaccard index)
HR [CI]
Extremity
rg [CI]
Extremity
Hits
Coloc Hits
FinRegistry
FinnGen
FinRegistry
FinnGen
FinnGen
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