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Cutaneous abscess, furuncle and carbuncle

EFO MESH Endpoint Browser PheWeb

L12_ABSCESS_CUT

Endpoint definition

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Endpoint definition steps

FinnGen

Phenotype data

473681

1. Apply sex-specific rule

None

473681

2. Check conditions

None

473681

3. Check pre-conditions, main-only, mode, registry filters

Registry filters:

  • Hospital discharge: ICD-10 — L02
  • Hospital discharge: ICD-9 — 680
  • Hospital discharge: ICD-8 — 680
  • Cause of death: ICD-10 — L02
  • Cause of death: ICD-9 — 680
  • Cause of death: ICD-8 — 680

2 out of 7 registries used, show all original rules.

10720

4. Check minimum number of events

None

10720

5. Include endpoints

None

10720

6. Filter based on genotype QC (FinnGen only)

10296

Control definitions (FinnGen only)

Control exclude L12_INFECT_SKIN

Extra metadata

Level in the ICD hierarchy 3
First used in FinnGen datafreeze DF2
Parent code in ICD-10 L00-L08
Name in latin Abscessus/furunculus/carbunculus cutis

Case counts by codes

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FinnGen case counts by registry codes:

generic upset plot

Upset plot

Full data table

Summary Statistics

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-FinRegistry-

Key figures

All Female Male
Number of individuals
Whole population 100713 42886 57060
Only index persons 90210 38966 51244
Unadjusted period prevalence (%)
Whole population 1.43 1.23 1.59
Only index persons 1.73 1.43 1.96
Median age at first event (years)
Whole population 42.96 43.69 42.46
Only index persons 42.70 43.49 42.11

-FinnGen-

Key figures

All Female Male
Number of individuals 10296 5126 5170
Unadjusted period prevalence (%) 2.31 2.01 2.60
Median age at first event (years) 49.61 46.84 52.35

-FinRegistry-

Age distribution of first events

-FinnGen-

Age distribution of first events

-FinRegistry-

Year distribution of first events

-FinnGen-

Year distribution of first events

-FinRegistry-

Cumulative Incidence Function

-FinnGen-

Cumulative Incidence Function

Mortality – FinRegistry

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Association

Association between endpoint L12_ABSCESS_CUT and mortality.

Females

Parameter HR [95% CI] p-value
L12_ABSCESS_CUT 2.447 [2.18, 2.74] < 0.001
Birth year 0.993 [0.99, 1.0] 0.078

During the follow-up period (1.1.1998 — 31.12.2019), 5007 out of 32767 females with L12_ABSCESS_CUT died.

Males

Parameter HR [95% CI] p-value
L12_ABSCESS_CUT 2.462 [2.21, 2.74] < 0.001
Birth year 0.986 [0.98, 1.0] 0.003

During the follow-up period (1.1.1998 — 31.12.2019), 7822 out of 43469 males with L12_ABSCESS_CUT died.

Mortality risk

Mortality risk for people of age

years, who have L12_ABSCESS_CUT.

N-year risk Females Males
1 0.239% 0.54%
5 1.446% 2.606%
10 3.297% 6.473%
15 5.896% 12.31%
20 10.675% 19.756%

Relationships between endpoints

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Index endpoint: L12_ABSCESS_CUT – Cutaneous abscess, furuncle and carbuncle

GWS hits: 1

Endpoint
Case Overlap
Survival Analysis
Genetic Correlations
Genetic Signals
N (Jaccard index)
HR [CI]
Extremity
rg [CI]
Extremity
Hits
Coloc Hits
FinRegistry
FinnGen
FinRegistry
FinnGen
FinnGen
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