hypothyroidism: Abnormally low levels of thyroid hormone.
Endpoint definition
↥
Endpoint definition steps |
FinnGen |
|---|---|
Phenotype data |
473681 |
1. Apply sex-specific ruleNone |
473681 |
2. Check conditionsNone |
473681 |
3. Check pre-conditions, main-only, mode, registry filtersRegistry filters:
1 out of 7 registries used, show all original rules. |
15037 |
4. Check minimum number of eventsNone |
15037 |
5. Include endpointsNone |
15037 |
6. Filter based on genotype QC (FinnGen only) |
14521 |
Control definitions (FinnGen only)
Control exclude
E4_MALNUTRITION, E4_DIABETES, I9_CVD, C3_CANCER, MENINGITIS, ENCEPHALITIS, HYPOTHYROIDISM, D3_ANAEMIA, F5_ALLANXIOUS, F5_MOOD, F5_SCHIZO, F5_BEHEMOCHILD, F5_UNSMENDIS, ANOSMIA, ANTIDEPRESSANTS
Extra metadata
First used in FinnGen datafreeze
DF3
Hypothyroidism, drug reimbursement
based on the number of shared cases.
Similar with more cases:
Similar with less cases:
Summary Statistics
↥-FinRegistry-
Key figures
| All | Female | Male | |
|---|---|---|---|
| Number of individuals | |||
| Whole population | 127566 | 105615 | 21123 |
| Only index persons | 107457 | 90351 | 17106 |
| Unadjusted period prevalence (%) | |||
| Whole population | 2.61 | 3.03 | 0.59 |
| Only index persons | 2.90 | 3.32 | 0.65 |
| Median age at first event (years) | |||
| Whole population | 51.91 | 51.67 | 52.89 |
| Only index persons | 49.93 | 49.83 | 50.42 |
-FinnGen-
Key figures
| All | Female | Male | |
|---|---|---|---|
| Number of individuals | 14521 | 12031 | 2490 |
| Unadjusted period prevalence (%) | 4.13 | 4.73 | 1.25 |
| Median age at first event (years) | 47.76 | 46.64 | 53.19 |
-FinRegistry-
Age distribution of first events
-FinnGen-
Age distribution of first events
-FinRegistry-
Year distribution of first events
-FinnGen-
Year distribution of first events
-FinRegistry-
Cumulative Incidence Function
-FinnGen-
Cumulative Incidence Function
Mortality – FinRegistry
↥Association
Association between endpoint HYPOTHY_REIMB and mortality.
Females
| Parameter | HR [95% CI] | p-value |
|---|---|---|
| HYPOTHY_REIMB | 0.981 [0.92, 1.05] | 0.572 |
| Birth year | 0.994 [0.99, 1.0] | 0.109 |
During the follow-up period (1.1.1998 — 31.12.2019), 7221 out of 47545 females with HYPOTHY_REIMB died.
Males
| Parameter | HR [95% CI] | p-value |
|---|---|---|
| HYPOTHY_REIMB | 1.107 [1.02, 1.2] | 0.012 |
| Birth year | 0.986 [0.98, 1.0] | 0.003 |
During the follow-up period (1.1.1998 — 31.12.2019), 2736 out of 11273 males with HYPOTHY_REIMB died.
Mortality risk
Mortality risk for people of age
years, who have HYPOTHY_REIMB.| N-year risk | Females | Males |
|---|---|---|
| 1 | 0.103% | 0.233% |
| 5 | 0.517% | 1.248% |
| 10 | 1.297% | 3.056% |
| 15 | 2.468% | 5.978% |
| 20 | 4.255% | 10.496% |
Relationships between endpoints
↥Index endpoint: HYPOTHY_REIMB – Hypothyroidism, drug reimbursement
GWS hits: 27
Endpoint
Case Overlap
Survival Analysis
Genetic Correlations
Genetic Signals
N (Jaccard index)
HR [CI]
Extremity
rg [CI]
Extremity
Hits
Coloc Hits
FinRegistry
FinnGen
FinRegistry
FinnGen
FinnGen
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