≡ Risteys
FG R11 + FR

Documentation Changelog GitHub Contact & Feedback

Anosmia

EFO Endpoint Browser PheWeb

ANOSMIA

Endpoint definition

↥

Endpoint definition steps

FinnGen

Phenotype data

473681

1. Apply sex-specific rule

None

473681

2. Check conditions

None

473681

3. Check pre-conditions, main-only, mode, registry filters

Registry filters:

  • Hospital discharge: ICD-10 — G52.0, R43.0
  • Hospital discharge: ICD-9 — 3520
  • Hospital discharge: ICD-8 — 35600
  • Cause of death: ICD-10 — G52.0, R43.0
  • Cause of death: ICD-9 — 3520
  • Cause of death: ICD-8 — 35600

2 out of 7 registries used, show all original rules.

917

4. Check minimum number of events

None

917

5. Include endpoints

None

917

6. Filter based on genotype QC (FinnGen only)

901

Control definitions (FinnGen only)

Control exclude NEURO_COMORBIDITIES

Extra metadata

First used in FinnGen datafreeze DF2

Case counts by codes

↥

FinnGen case counts by registry codes:

generic upset plot

Upset plot

Full data table

Summary Statistics

↥

-FinRegistry-

Key figures

All Female Male
Number of individuals
Whole population 5836 3712 2100
Only index persons 5668 3636 2032
Unadjusted period prevalence (%)
Whole population 0.09 0.11 0.06
Only index persons 0.11 0.13 0.08
Median age at first event (years)
Whole population 56.21 56.84 55.27
Only index persons 56.18 56.77 55.13

-FinnGen-

Key figures

All Female Male
Number of individuals 901 608 293
Unadjusted period prevalence (%) 0.21 0.24 0.15
Median age at first event (years) 56.84 56.33 57.90

-FinRegistry-

Age distribution of first events

-FinnGen-

Age distribution of first events

-FinRegistry-

Year distribution of first events

-FinnGen-

Year distribution of first events

-FinRegistry-

Cumulative Incidence Function

-FinnGen-

Cumulative Incidence Function

Mortality – FinRegistry

↥

Association

Association between endpoint ANOSMIA and mortality.

Females

Parameter HR [95% CI] p-value
ANOSMIA 0.808 [0.71, 0.92] 0.002
Birth year 0.996 [0.99, 1.0] 0.364

During the follow-up period (1.1.1998 — 31.12.2019), 303 out of 3408 females with ANOSMIA died.

Males

Parameter HR [95% CI] p-value
ANOSMIA 0.872 [0.75, 1.01] 0.076
Birth year 0.986 [0.98, 1.0] 0.005

During the follow-up period (1.1.1998 — 31.12.2019), 253 out of 1920 males with ANOSMIA died.

Mortality risk

Mortality risk for people of age

years, who have ANOSMIA.

N-year risk Females Males
1 0.081% 0.157%
5 0.549% 0.977%
10 1.229% 2.494%
15 2.272% 4.668%
20 4.087% 8.128%

Relationships between endpoints

↥

Index endpoint: ANOSMIA – Anosmia

GWS hits: 1

Endpoint
Case Overlap
Survival Analysis
Genetic Correlations
Genetic Signals
N (Jaccard index)
HR [CI]
Extremity
rg [CI]
Extremity
Hits
Coloc Hits
FinRegistry
FinnGen
FinRegistry
FinnGen
FinnGen
loading spinner Loading data