No definition available.
Endpoint definition
↥
Endpoint definition steps |
FinnGen |
|---|---|
Phenotype data |
473681 |
1. Apply sex-specific ruleNone |
473681 |
2. Check conditionsNone |
473681 |
3. Check pre-conditions, main-only, mode, registry filtersNone 0 out of 7 registries used, show all original rules. |
0 |
4. Check minimum number of eventsNone |
0 |
5. Include endpoints |
1745 |
6. Filter based on genotype QC (FinnGen only) |
1684 |
Control definitions (FinnGen only)
Control exclude
AB1_VIRAL_CNS
Extra metadata
First used in FinnGen datafreeze
DF2
Meningitis
based on the number of shared cases.
Similar with more cases:
Similar with less cases:
Summary Statistics
↥-FinRegistry-
Key figures
| All | Female | Male | |
|---|---|---|---|
| Number of individuals | |||
| Whole population | 18175 | 8439 | 9598 |
| Only index persons | 14933 | 7258 | 7675 |
| Unadjusted period prevalence (%) | |||
| Whole population | 0.25 | 0.24 | 0.27 |
| Only index persons | 0.28 | 0.27 | 0.29 |
| Median age at first event (years) | |||
| Whole population | 29.98 | 32.14 | 27.70 |
| Only index persons | 26.99 | 29.97 | 24.16 |
-FinnGen-
Key figures
| All | Female | Male | |
|---|---|---|---|
| Number of individuals | 1684 | 940 | 744 |
| Unadjusted period prevalence (%) | 0.37 | 0.37 | 0.37 |
| Median age at first event (years) | 32.85 | 31.78 | 34.20 |
-FinRegistry-
Age distribution of first events
-FinnGen-
Age distribution of first events
-FinRegistry-
Year distribution of first events
-FinnGen-
Year distribution of first events
-FinRegistry-
Cumulative Incidence Function
-FinnGen-
Cumulative Incidence Function
Mortality – FinRegistry
↥Association
Association between endpoint MENINGITIS and mortality.
Females
| Parameter | HR [95% CI] | p-value |
|---|---|---|
| MENINGITIS | 2.303 [1.99, 2.66] | < 0.001 |
| Birth year | 0.995 [0.99, 1.0] | 0.211 |
During the follow-up period (1.1.1998 — 31.12.2019), 686 out of 3805 females with MENINGITIS died.
Males
| Parameter | HR [95% CI] | p-value |
|---|---|---|
| MENINGITIS | 2.327 [2.0, 2.71] | < 0.001 |
| Birth year | 0.986 [0.98, 1.0] | 0.004 |
During the follow-up period (1.1.1998 — 31.12.2019), 823 out of 3963 males with MENINGITIS died.
Mortality risk
Mortality risk for people of age
years, who have MENINGITIS.| N-year risk | Females | Males |
|---|---|---|
| 1 | 0.233% | 0.438% |
| 5 | 1.237% | 2.553% |
| 10 | 3.441% | 6.493% |
| 15 | 6.682% | 11.706% |
| 20 | 10.829% | 19.098% |
Relationships between endpoints
↥Index endpoint: MENINGITIS – Meningitis
GWS hits: -
Endpoint
Case Overlap
Survival Analysis
Genetic Correlations
Genetic Signals
N (Jaccard index)
HR [CI]
Extremity
rg [CI]
Extremity
Hits
Coloc Hits
FinRegistry
FinnGen
FinRegistry
FinnGen
FinnGen
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