infectious meningitis: Inflammation of the meninges of the brain and/or spinal cord caused by an infectious agent (viral, bacterial, or fungal). Symptoms include headache, fever, vomiting, neck stiffness, photophobia, confusion, and seizures.
Endpoint definition
↥
Endpoint definition steps |
FinnGen |
|---|---|
Phenotype data |
473681 |
1. Apply sex-specific ruleNone |
473681 |
2. Check conditionsNone |
473681 |
3. Check pre-conditions, main-only, mode, registry filtersRegistry filters:
2 out of 7 registries used, show all original rules. |
517 |
4. Check minimum number of eventsNone |
517 |
5. Include endpointsNone |
517 |
6. Filter based on genotype QC (FinnGen only) |
495 |
Control definitions (FinnGen only)
Control exclude
G6_NEUINFL
Extra metadata
Level in the ICD hierarchy
3
First used in FinnGen datafreeze
DF2
Similar endpoints
↥List of similar endpoints to
Other meningitis
based on the number of shared cases.
Similar with more cases:
- Meningitis
- Inflammatory diseases of the central nervous system
- Neurological diseases
- Neurological diseases
- Any event in hilmo or specialist outpatient
Similar with less cases:
None
Case counts by codes
↥
Summary Statistics
↥-FinRegistry-
Key figures
| All | Female | Male | |
|---|---|---|---|
| Number of individuals | |||
| Whole population | 4841 | 2409 | 2393 |
| Only index persons | 4163 | 2151 | 2012 |
| Unadjusted period prevalence (%) | |||
| Whole population | 0.07 | 0.07 | 0.07 |
| Only index persons | 0.08 | 0.08 | 0.08 |
| Median age at first event (years) | |||
| Whole population | 40.27 | 41.58 | 38.59 |
| Only index persons | 37.69 | 39.51 | 35.74 |
-FinnGen-
Key figures
| All | Female | Male | |
|---|---|---|---|
| Number of individuals | 495 | 315 | 180 |
| Unadjusted period prevalence (%) | 0.11 | 0.12 | 0.09 |
| Median age at first event (years) | 42.46 | 40.87 | 45.23 |
-FinRegistry-
Age distribution of first events
-FinnGen-
Age distribution of first events
-FinRegistry-
Year distribution of first events
-FinnGen-
Year distribution of first events
-FinRegistry-
Cumulative Incidence Function
-FinnGen-
Cumulative Incidence Function
No data
Mortality – FinRegistry
↥Association
Association between endpoint G6_MENINGOTH and mortality.
Females
| Parameter | HR [95% CI] | p-value |
|---|---|---|
| G6_MENINGOTH | 2.298 [1.88, 2.8] | < 0.001 |
| Birth year | 0.993 [0.98, 1.0] | 0.112 |
During the follow-up period (1.1.1998 — 31.12.2019), 318 out of 1695 females with G6_MENINGOTH died.
Males
| Parameter | HR [95% CI] | p-value |
|---|---|---|
| G6_MENINGOTH | 2.392 [1.93, 2.96] | < 0.001 |
| Birth year | 0.988 [0.98, 1.0] | 0.026 |
During the follow-up period (1.1.1998 — 31.12.2019), 335 out of 1631 males with G6_MENINGOTH died.
Mortality risk
Mortality risk for people of age
years, who have G6_MENINGOTH.| N-year risk | Females | Males |
|---|---|---|
| 1 | 0.192% | 0.399% |
| 5 | 1.228% | 2.535% |
| 10 | 3.051% | 6.679% |
| 15 | 5.931% | 12.873% |
| 20 | 10.511% | 21.46% |
Relationships between endpoints
↥Index endpoint: G6_MENINGOTH – Other meningitis
GWS hits: -
Endpoint
Case Overlap
Survival Analysis
Genetic Correlations
Genetic Signals
N (Jaccard index)
HR [CI]
Extremity
rg [CI]
Extremity
Hits
Coloc Hits
FinRegistry
FinnGen
FinRegistry
FinnGen
FinnGen
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