encephalomyelitis: Inflammation of the brain and the spinal cord.
Endpoint definition
↥
Endpoint definition steps |
FinnGen |
|---|---|
Phenotype data |
473681 |
1. Apply sex-specific ruleNone |
473681 |
2. Check conditionsNone |
473681 |
3. Check pre-conditions, main-only, mode, registry filtersRegistry filters: 2 out of 7 registries used, show all original rules. |
2063 |
4. Check minimum number of eventsNone |
2063 |
5. Include endpoints |
3025 |
6. Filter based on genotype QC (FinnGen only) |
2913 |
Control definitions (FinnGen only)
Controls for this endpoint are individuals that are not cases.
Extra metadata
Level in the ICD hierarchy
2
First used in FinnGen datafreeze
DF2
Inflammatory diseases of the central nervous system
based on the number of shared cases.
Similar with more cases:
Similar with less cases:
Summary Statistics
↥-FinRegistry-
Key figures
| All | Female | Male | |
|---|---|---|---|
| Number of individuals | |||
| Whole population | 30865 | 14355 | 16249 |
| Only index persons | 25199 | 12176 | 13023 |
| Unadjusted period prevalence (%) | |||
| Whole population | 0.43 | 0.41 | 0.45 |
| Only index persons | 0.47 | 0.45 | 0.50 |
| Median age at first event (years) | |||
| Whole population | 36.98 | 38.34 | 35.46 |
| Only index persons | 33.30 | 35.46 | 31.28 |
-FinnGen-
Key figures
| All | Female | Male | |
|---|---|---|---|
| Number of individuals | 2913 | 1565 | 1348 |
| Unadjusted period prevalence (%) | 0.64 | 0.61 | 0.68 |
| Median age at first event (years) | 40.43 | 36.25 | 45.28 |
-FinRegistry-
Age distribution of first events
-FinnGen-
Age distribution of first events
-FinRegistry-
Year distribution of first events
-FinnGen-
Year distribution of first events
-FinRegistry-
Cumulative Incidence Function
-FinnGen-
Cumulative Incidence Function
Mortality – FinRegistry
↥Association
Association between endpoint G6_NEUINFL and mortality.
Females
| Parameter | HR [95% CI] | p-value |
|---|---|---|
| G6_NEUINFL | 2.497 [2.2, 2.84] | < 0.001 |
| Birth year | 0.996 [0.99, 1.0] | 0.389 |
During the follow-up period (1.1.1998 — 31.12.2019), 1652 out of 7552 females with G6_NEUINFL died.
Males
| Parameter | HR [95% CI] | p-value |
|---|---|---|
| G6_NEUINFL | 2.74 [2.21, 3.4] | < 0.001 |
| Birth year | 0.983 [0.92, 1.05] | 0.626 |
During the follow-up period (1.1.1998 — 31.12.2019), 1966 out of 7915 males with G6_NEUINFL died.
Mortality risk
Mortality risk for people of age
years, who have G6_NEUINFL.| N-year risk | Females | Males |
|---|---|---|
| 1 | 0.258% | 0.562% |
| 5 | 1.414% | 2.811% |
| 10 | 3.869% | 6.966% |
| 15 | 7.369% | 13.161% |
| 20 | 13.182% | 21.618% |
Relationships between endpoints
↥Index endpoint: G6_NEUINFL – Inflammatory diseases of the central nervous system
GWS hits: -
Endpoint
Case Overlap
Survival Analysis
Genetic Correlations
Genetic Signals
N (Jaccard index)
HR [CI]
Extremity
rg [CI]
Extremity
Hits
Coloc Hits
FinRegistry
FinnGen
FinRegistry
FinnGen
FinnGen
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