Inflammatory diseases of the central nervous system

G6_NEUINFL

Endpoint definition

Endpoint definition steps

FinnGen

Phenotype data

473681

1. Apply sex-specific rule

None

473681

2. Check conditions

None

473681

3. Check pre-conditions, main-only, mode, registry filters

Registry filters:

  • Hospital discharge: ICD-10 G00-G09
  • Cause of death: ICD-10 G00-G09

2 out of 7 registries used, show all original rules.

2063

4. Check minimum number of events

None

2063

5. Include endpoints

3025

6. Filter based on genotype QC (FinnGen only)

2913

Control definitions (FinnGen only)

Controls for this endpoint are individuals that are not cases.

Extra metadata

Level in the ICD hierarchy 2
First used in FinnGen datafreeze DF2

Case counts by codes

FinnGen case counts by registry codes:

generic upset plot

Upset plot

Full data table

Summary Statistics

-FinRegistry-

Key figures

All Female Male
Number of individuals
Whole population 30865 14355 16249
Only index persons 25199 12176 13023
Unadjusted period prevalence (%)
Whole population 0.43 0.41 0.45
Only index persons 0.47 0.45 0.50
Median age at first event (years)
Whole population 36.98 38.34 35.46
Only index persons 33.30 35.46 31.28

-FinnGen-

Key figures

All Female Male
Number of individuals 2913 1565 1348
Unadjusted period prevalence (%) 0.64 0.61 0.68
Median age at first event (years) 40.43 36.25 45.28

-FinRegistry-

Age distribution of first events

-FinnGen-

Age distribution of first events

-FinRegistry-

Year distribution of first events

-FinnGen-

Year distribution of first events

-FinRegistry-

Cumulative Incidence Function

-FinnGen-

Cumulative Incidence Function

Mortality – FinRegistry

Association

Association between endpoint G6_NEUINFL and mortality.

Females

Parameter HR [95% CI] p-value
G6_NEUINFL 2.497 [2.2, 2.84] < 0.001
Birth year 0.996 [0.99, 1.0] 0.389

During the follow-up period (1.1.1998 — 31.12.2019), 1652 out of 7552 females with G6_NEUINFL died.

Males

Parameter HR [95% CI] p-value
G6_NEUINFL 2.74 [2.21, 3.4] < 0.001
Birth year 0.983 [0.92, 1.05] 0.626

During the follow-up period (1.1.1998 — 31.12.2019), 1966 out of 7915 males with G6_NEUINFL died.

Mortality risk

Mortality risk for people of age

years, who have G6_NEUINFL.

N-year risk Females Males
1 0.258% 0.562%
5 1.414% 2.811%
10 3.869% 6.966%
15 7.369% 13.161%
20 13.182% 21.618%

Relationships between endpoints

Index endpoint: G6_NEUINFL – Inflammatory diseases of the central nervous system

GWS hits: -

Endpoint
Case Overlap
Survival Analysis
Genetic Correlations
Genetic Signals
N (Jaccard index)
HR [CI]
Extremity
rg [CI]
Extremity
Hits
Coloc Hits
FinRegistry
FinnGen
FinRegistry
FinnGen
FinnGen
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