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Bacterial meningitis

DOID EFO Endpoint Browser PheWeb

G6_MENINGBACT

bacterial meningitis: Inflammation of the membranes surrounding the brain and spinal cord due to a bacterial infection.

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Endpoint definition

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Endpoint definition steps

FinnGen

Phenotype data

473681

1. Apply sex-specific rule

None

473681

2. Check conditions

None

473681

3. Check pre-conditions, main-only, mode, registry filters

Registry filters:

  • Hospital discharge: ICD-10 — G0[0-1]
  • Hospital discharge: ICD-9 — 320
  • Hospital discharge: ICD-8 — 320
  • Cause of death: ICD-10 — G0[0-1]
  • Cause of death: ICD-9 — 320
  • Cause of death: ICD-8 — 320

2 out of 7 registries used, show all original rules.

1180

4. Check minimum number of events

None

1180

5. Include endpoints

None

1180

6. Filter based on genotype QC (FinnGen only)

1142

Control definitions (FinnGen only)

Control exclude G6_NEUINFL

Extra metadata

Level in the ICD hierarchy 3
First used in FinnGen datafreeze DF2

Case counts by codes

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FinnGen case counts by registry codes:

generic upset plot

Upset plot

Full data table

Summary Statistics

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-FinRegistry-

Key figures

All Female Male
Number of individuals
Whole population 13164 5855 7210
Only index persons 10528 4917 5611
Unadjusted period prevalence (%)
Whole population 0.19 0.17 0.20
Only index persons 0.20 0.18 0.21
Median age at first event (years)
Whole population 26.64 28.04 25.10
Only index persons 22.93 25.96 20.28

-FinnGen-

Key figures

All Female Male
Number of individuals 1142 591 551
Unadjusted period prevalence (%) 0.25 0.23 0.28
Median age at first event (years) 27.79 26.83 28.81

-FinRegistry-

Age distribution of first events

-FinnGen-

Age distribution of first events

-FinRegistry-

Year distribution of first events

-FinnGen-

Year distribution of first events

-FinRegistry-

Cumulative Incidence Function

-FinnGen-

Cumulative Incidence Function

Mortality – FinRegistry

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Association

Association between endpoint G6_MENINGBACT and mortality.

Females

Parameter HR [95% CI] p-value
G6_MENINGBACT 2.439 [2.05, 2.9] < 0.001
Birth year 0.996 [0.99, 1.0] 0.339

During the follow-up period (1.1.1998 — 31.12.2019), 366 out of 1921 females with G6_MENINGBACT died.

Males

Parameter HR [95% CI] p-value
G6_MENINGBACT 2.511 [2.12, 2.98] < 0.001
Birth year 0.987 [0.98, 1.0] 0.005

During the follow-up period (1.1.1998 — 31.12.2019), 528 out of 2305 males with G6_MENINGBACT died.

Mortality risk

Mortality risk for people of age

years, who have G6_MENINGBACT.

N-year risk Females Males
1 0.233% 0.462%
5 1.41% 3.008%
10 3.352% 7.395%
15 6.994% 13.678%
20 12.009% 22.485%

Relationships between endpoints

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Index endpoint: G6_MENINGBACT – Bacterial meningitis

GWS hits: -

Endpoint
Case Overlap
Survival Analysis
Genetic Correlations
Genetic Signals
N (Jaccard index)
HR [CI]
Extremity
rg [CI]
Extremity
Hits
Coloc Hits
FinRegistry
FinnGen
FinRegistry
FinnGen
FinnGen
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