No definition available.
Endpoint definition
↥
Endpoint definition steps |
FinnGen |
|---|---|
Phenotype data |
473681 |
1. Apply sex-specific ruleNone |
473681 |
2. Check conditionsNone |
473681 |
3. Check pre-conditions, main-only, mode, registry filtersRegistry filters:
2 out of 7 registries used, show all original rules. |
892 |
4. Check minimum number of eventsNone |
892 |
5. Include endpointsNone |
892 |
6. Filter based on genotype QC (FinnGen only) |
853 |
Control definitions (FinnGen only)
Control exclude
G6_NEUINFL
Extra metadata
Level in the ICD hierarchy
3
First used in FinnGen datafreeze
DF2
Similar endpoints
↥List of similar endpoints to
Other encephalitis
based on the number of shared cases.
Similar with more cases:
- Encephalitis
- Inflammatory diseases of the central nervous system
- Neurological diseases
- Neurological diseases
- Any event in hilmo or specialist outpatient
Similar with less cases:
None
Case counts by codes
↥
Summary Statistics
↥-FinRegistry-
Key figures
| All | Female | Male | |
|---|---|---|---|
| Number of individuals | |||
| Whole population | 8321 | 4179 | 4069 |
| Only index persons | 7092 | 3622 | 3470 |
| Unadjusted period prevalence (%) | |||
| Whole population | 0.12 | 0.12 | 0.11 |
| Only index persons | 0.13 | 0.13 | 0.13 |
| Median age at first event (years) | |||
| Whole population | 44.69 | 46.74 | 42.37 |
| Only index persons | 42.17 | 44.29 | 39.97 |
-FinnGen-
Key figures
| All | Female | Male | |
|---|---|---|---|
| Number of individuals | 853 | 463 | 390 |
| Unadjusted period prevalence (%) | 0.19 | 0.18 | 0.20 |
| Median age at first event (years) | 47.92 | 43.38 | 53.30 |
-FinRegistry-
Age distribution of first events
-FinnGen-
Age distribution of first events
-FinRegistry-
Year distribution of first events
-FinnGen-
Year distribution of first events
-FinRegistry-
Cumulative Incidence Function
-FinnGen-
Cumulative Incidence Function
Mortality – FinRegistry
↥Association
Association between endpoint G6_ENCEPHOTH and mortality.
Females
| Parameter | HR [95% CI] | p-value |
|---|---|---|
| G6_ENCEPHOTH | 2.45 [2.02, 2.98] | < 0.001 |
| Birth year | 0.991 [0.98, 1.0] | 0.037 |
During the follow-up period (1.1.1998 — 31.12.2019), 661 out of 2876 females with G6_ENCEPHOTH died.
Males
| Parameter | HR [95% CI] | p-value |
|---|---|---|
| G6_ENCEPHOTH | 2.573 [2.12, 3.12] | < 0.001 |
| Birth year | 0.987 [0.98, 1.0] | 0.009 |
During the follow-up period (1.1.1998 — 31.12.2019), 676 out of 2598 males with G6_ENCEPHOTH died.
Mortality risk
Mortality risk for people of age
years, who have G6_ENCEPHOTH.| N-year risk | Females | Males |
|---|---|---|
| 1 | 0.27% | 0.56% |
| 5 | 1.504% | 3.404% |
| 10 | 3.471% | 7.97% |
| 15 | 6.499% | 14.497% |
| 20 | 10.676% | 23.104% |
Relationships between endpoints
↥Index endpoint: G6_ENCEPHOTH – Other encephalitis
GWS hits: -
Endpoint
Case Overlap
Survival Analysis
Genetic Correlations
Genetic Signals
N (Jaccard index)
HR [CI]
Extremity
rg [CI]
Extremity
Hits
Coloc Hits
FinRegistry
FinnGen
FinRegistry
FinnGen
FinnGen
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