No definition available.
Endpoint definition
↥
Endpoint definition steps |
FinnGen |
|---|---|
Phenotype data |
473681 |
1. Apply sex-specific ruleNone |
473681 |
2. Check conditionsNone |
473681 |
3. Check pre-conditions, main-only, mode, registry filtersRegistry filters:
2 out of 7 registries used, show all original rules. |
352 |
4. Check minimum number of eventsNone |
352 |
5. Include endpointsNone |
352 |
6. Filter based on genotype QC (FinnGen only) |
340 |
Control definitions (FinnGen only)
Control exclude
G6_NEUINFL
Extra metadata
Level in the ICD hierarchy
3
First used in FinnGen datafreeze
DF2
Similar endpoints
↥List of similar endpoints to
Intracranial and intraspinal abscess and granuloma
based on the number of shared cases.
Similar with more cases:
- Inflammatory diseases of the central nervous system
- Neurological diseases
- Neurological diseases
- Any event in hilmo or specialist outpatient
Similar with less cases:
None
Case counts by codes
↥
Summary Statistics
↥-FinRegistry-
Key figures
| All | Female | Male | |
|---|---|---|---|
| Number of individuals | |||
| Whole population | 3266 | 1188 | 2050 |
| Only index persons | 2599 | 978 | 1621 |
| Unadjusted period prevalence (%) | |||
| Whole population | 0.05 | 0.03 | 0.06 |
| Only index persons | 0.05 | 0.04 | 0.06 |
| Median age at first event (years) | |||
| Whole population | 56.24 | 57.43 | 55.51 |
| Only index persons | 55.94 | 56.94 | 55.33 |
-FinnGen-
Key figures
| All | Female | Male | |
|---|---|---|---|
| Number of individuals | 340 | 137 | 203 |
| Unadjusted period prevalence (%) | 0.08 | 0.05 | 0.10 |
| Median age at first event (years) | 58.49 | 54.57 | 61.13 |
-FinRegistry-
Age distribution of first events
-FinnGen-
Age distribution of first events
-FinRegistry-
Year distribution of first events
-FinnGen-
Year distribution of first events
-FinRegistry-
Cumulative Incidence Function
-FinnGen-
Cumulative Incidence Function
Mortality – FinRegistry
↥Association
Association between endpoint G6_CNSABSC and mortality.
Females
| Parameter | HR [95% CI] | p-value |
|---|---|---|
| G6_CNSABSC | 2.858 [2.2, 3.71] | < 0.001 |
| Birth year | 0.996 [0.99, 1.0] | 0.345 |
During the follow-up period (1.1.1998 — 31.12.2019), 249 out of 827 females with G6_CNSABSC died.
Males
| Parameter | HR [95% CI] | p-value |
|---|---|---|
| G6_CNSABSC | 3.057 [2.48, 3.77] | < 0.001 |
| Birth year | 0.984 [0.97, 0.99] | 0.002 |
During the follow-up period (1.1.1998 — 31.12.2019), 456 out of 1360 males with G6_CNSABSC died.
Mortality risk
Mortality risk for people of age
years, who have G6_CNSABSC.| N-year risk | Females | Males |
|---|---|---|
| 1 | 0.342% | 0.607% |
| 5 | 2.032% | 3.043% |
| 10 | 4.479% | 7.957% |
| 15 | 7.857% | 15.197% |
| 20 | 13.336% | 24.356% |
Relationships between endpoints
↥Index endpoint: G6_CNSABSC – Intracranial and intraspinal abscess and granuloma
GWS hits: -
Endpoint
Case Overlap
Survival Analysis
Genetic Correlations
Genetic Signals
N (Jaccard index)
HR [CI]
Extremity
rg [CI]
Extremity
Hits
Coloc Hits
FinRegistry
FinnGen
FinRegistry
FinnGen
FinnGen
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