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Sequelae of inflammatory diseases of the central nervous system

DOID Endpoint Browser PheWeb

G6_NEUROINFSEQ

Endpoint definition

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Endpoint definition steps

FinnGen

Phenotype data

473681

1. Apply sex-specific rule

None

473681

2. Check conditions

None

473681

3. Check pre-conditions, main-only, mode, registry filters

Registry filters:

  • Hospital discharge: ICD-10 — G09
  • Hospital discharge: ICD-9 — 326
  • Hospital discharge: ICD-8 — 324
  • Cause of death: ICD-10 — G09
  • Cause of death: ICD-9 — 326
  • Cause of death: ICD-8 — 324

2 out of 7 registries used, show all original rules.

97

4. Check minimum number of events

None

97

5. Include endpoints

None

97

6. Filter based on genotype QC (FinnGen only)

94

Control definitions (FinnGen only)

Control exclude G6_NEUINFL

Extra metadata

Level in the ICD hierarchy 3
First used in FinnGen datafreeze DF2
Parent code in ICD-10 G00-G09
Name in latin Sequelae morborum inflammatoriorum systematis nervosi centralis

Case counts by codes

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FinnGen case counts by registry codes:

generic upset plot

Upset plot

Full data table

Summary Statistics

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-FinRegistry-

Key figures

All Female Male
Number of individuals
Whole population 1421 653 746
Only index persons 880 437 443
Unadjusted period prevalence (%)
Whole population 0.02 0.02 0.02
Only index persons 0.02 0.02 0.02
Median age at first event (years)
Whole population 43.55 45.47 41.45
Only index persons 36.06 39.65 32.52

-FinnGen-

Key figures

All Female Male
Number of individuals 94 44 50
Unadjusted period prevalence (%) 0.02 0.02 0.03
Median age at first event (years) 37.25 30.83 42.91

-FinRegistry-

Age distribution of first events

-FinnGen-

Age distribution of first events

-FinRegistry-

Year distribution of first events

-FinnGen-

Year distribution of first events

-FinRegistry-

Cumulative Incidence Function

-FinnGen-

Cumulative Incidence Function

No data

Mortality – FinRegistry

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Association

Association between endpoint G6_NEUROINFSEQ and mortality.

Females

Parameter HR [95% CI] p-value
G6_NEUROINFSEQ 2.449 [1.58, 3.79] < 0.001
Birth year 0.995 [0.99, 1.0] 0.263

During the follow-up period (1.1.1998 — 31.12.2019), 65 out of 211 females with G6_NEUROINFSEQ died.

Males

No data

Mortality risk

Mortality risk for people of age

years, who have G6_NEUROINFSEQ.

N-year risk Females Males
1 0.273% No data
5 1.534% No data
10 3.802% No data
15 6.743% No data
20 11.591% No data

Relationships between endpoints

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Index endpoint: G6_NEUROINFSEQ – Sequelae of inflammatory diseases of the central nervous system

GWS hits: -

Endpoint
Case Overlap
Survival Analysis
Genetic Correlations
Genetic Signals
N (Jaccard index)
HR [CI]
Extremity
rg [CI]
Extremity
Hits
Coloc Hits
FinRegistry
FinnGen
FinRegistry
FinnGen
FinnGen
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