viral meningitis: Viral infections of the leptomeninges and subarachnoid space. TOGAVIRIDAE INFECTIONS; FLAVIVIRIDAE INFECTIONS; RUBELLA; BUNYAVIRIDAE INFECTIONS; ORBIVIRUS infections; PICORNAVIRIDAE INFECTIONS; ORTHOMYXOVIRIDAE INFECTIONS; RHABDOVIRIDAE INFECTIONS; ARENAVIRIDAE INFECTIONS; HERPESVIRIDAE INFECTIONS; ADENOVIRIDAE INFECTIONS; JC VIRUS infections; and RETROVIRIDAE INFECTIONS may cause this form of meningitis. Clinical manifestations include fever, headache, neck pain, vomiting, PHOTOPHOBIA, and signs of meningeal irritation. (From Joynt, Clinical Neurology, 1996, Ch26, pp1-3)
Endpoint definition
↥
Endpoint definition steps |
FinnGen |
|---|---|
Phenotype data |
473681 |
1. Apply sex-specific ruleNone |
473681 |
2. Check conditionsNone |
473681 |
3. Check pre-conditions, main-only, mode, registry filtersRegistry filters:
2 out of 7 registries used, show all original rules. |
2401 |
4. Check minimum number of eventsNone |
2401 |
5. Include endpoints |
2713 |
6. Filter based on genotype QC (FinnGen only) |
2595 |
Control definitions (FinnGen only)
Controls for this endpoint are individuals that are not cases.
Extra metadata
Level in the ICD hierarchy
2
First used in FinnGen datafreeze
DF2
Viral infections of the central nervous system
based on the number of shared cases.
Similar with more cases:
Similar with less cases:
Summary Statistics
↥-FinRegistry-
Key figures
| All | Female | Male | |
|---|---|---|---|
| Number of individuals | |||
| Whole population | 26420 | 13206 | 13059 |
| Only index persons | 23392 | 11811 | 11581 |
| Unadjusted period prevalence (%) | |||
| Whole population | 0.37 | 0.38 | 0.36 |
| Only index persons | 0.44 | 0.43 | 0.44 |
| Median age at first event (years) | |||
| Whole population | 31.76 | 34.52 | 28.71 |
| Only index persons | 30.31 | 33.40 | 27.16 |
-FinnGen-
Key figures
| All | Female | Male | |
|---|---|---|---|
| Number of individuals | 2595 | 1550 | 1045 |
| Unadjusted period prevalence (%) | 0.57 | 0.61 | 0.52 |
| Median age at first event (years) | 35.69 | 34.24 | 37.84 |
-FinRegistry-
Age distribution of first events
-FinnGen-
Age distribution of first events
-FinRegistry-
Year distribution of first events
-FinnGen-
Year distribution of first events
-FinRegistry-
Cumulative Incidence Function
-FinnGen-
Cumulative Incidence Function
Mortality – FinRegistry
↥Association
Association between endpoint AB1_VIRAL_CNS and mortality.
Females
| Parameter | HR [95% CI] | p-value |
|---|---|---|
| AB1_VIRAL_CNS | 1.972 [1.72, 2.26] | < 0.001 |
| Birth year | 0.992 [0.98, 1.0] | 0.077 |
During the follow-up period (1.1.1998 — 31.12.2019), 1041 out of 7272 females with AB1_VIRAL_CNS died.
Males
| Parameter | HR [95% CI] | p-value |
|---|---|---|
| AB1_VIRAL_CNS | 1.907 [1.66, 2.2] | < 0.001 |
| Birth year | 0.987 [0.98, 1.0] | 0.006 |
During the follow-up period (1.1.1998 — 31.12.2019), 1073 out of 7452 males with AB1_VIRAL_CNS died.
Mortality risk
Mortality risk for people of age
years, who have AB1_VIRAL_CNS.| N-year risk | Females | Males |
|---|---|---|
| 1 | 0.143% | 0.403% |
| 5 | 1.046% | 2.112% |
| 10 | 2.439% | 5.56% |
| 15 | 4.779% | 10.616% |
| 20 | 8.764% | 17.503% |
Relationships between endpoints
↥Index endpoint: AB1_VIRAL_CNS – Viral infections of the central nervous system
GWS hits: -
Endpoint
Case Overlap
Survival Analysis
Genetic Correlations
Genetic Signals
N (Jaccard index)
HR [CI]
Extremity
rg [CI]
Extremity
Hits
Coloc Hits
FinRegistry
FinnGen
FinRegistry
FinnGen
FinnGen
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