Viral meningitis

AB1_VIRAL_MENINGITIS

Endpoint definition

Endpoint definition steps

FinnGen

Phenotype data

473681

1. Apply sex-specific rule

None

473681

2. Check conditions

None

473681

3. Check pre-conditions, main-only, mode, registry filters

Registry filters:

  • Hospital discharge: ICD-10 A87
  • Hospital discharge: ICD-9 04[7]
  • Hospital discharge: ICD-8 04[5]
  • Cause of death: ICD-10 A87
  • Cause of death: ICD-9 04[7]
  • Cause of death: ICD-8 04[5]

2 out of 7 registries used, show all original rules.

1331

4. Check minimum number of events

None

1331

5. Include endpoints

None

1331

6. Filter based on genotype QC (FinnGen only)

1274

Control definitions (FinnGen only)

Control exclude AB1_VIRAL_CNS

Extra metadata

Level in the ICD hierarchy 3
First used in FinnGen datafreeze DF5

Case counts by codes

FinnGen case counts by registry codes:

generic upset plot

Upset plot

Full data table

Summary Statistics

-FinRegistry-

Key figures

All Female Male
Number of individuals
Whole population 11978 5977 5953
Only index persons 11399 5736 5663
Unadjusted period prevalence (%)
Whole population 0.17 0.17 0.17
Only index persons 0.21 0.21 0.22
Median age at first event (years)
Whole population 25.37 29.38 21.26
Only index persons 25.37 29.40 21.28

-FinnGen-

Key figures

All Female Male
Number of individuals 1274 825 449
Unadjusted period prevalence (%) 0.29 0.32 0.23
Median age at first event (years) 31.06 31.01 31.14

-FinRegistry-

Age distribution of first events

-FinnGen-

Age distribution of first events

-FinRegistry-

Year distribution of first events

-FinnGen-

Year distribution of first events

-FinRegistry-

Cumulative Incidence Function

-FinnGen-

Cumulative Incidence Function

Mortality – FinRegistry

Association

Association between endpoint AB1_VIRAL_MENINGITIS and mortality.

Females

Parameter HR [95% CI] p-value
AB1_VIRAL_MENINGITIS 1.101 [0.92, 1.32] 0.301
Birth year 0.989 [0.98, 1.0] 0.015

During the follow-up period (1.1.1998 — 31.12.2019), 162 out of 4213 females with AB1_VIRAL_MENINGITIS died.

Males

Parameter HR [95% CI] p-value
AB1_VIRAL_MENINGITIS 0.997 [0.84, 1.19] 0.973
Birth year 0.989 [0.98, 1.0] 0.019

During the follow-up period (1.1.1998 — 31.12.2019), 177 out of 4014 males with AB1_VIRAL_MENINGITIS died.

Mortality risk

Mortality risk for people of age

years, who have AB1_VIRAL_MENINGITIS.

N-year risk Females Males
1 0.094% 0.179%
5 0.558% 1.211%
10 1.285% 3.248%
15 2.505% 5.883%
20 4.447% 10.229%

Relationships between endpoints

Index endpoint: AB1_VIRAL_MENINGITIS – Viral meningitis

GWS hits: -

Endpoint
Case Overlap
Survival Analysis
Genetic Correlations
Genetic Signals
N (Jaccard index)
HR [CI]
Extremity
rg [CI]
Extremity
Hits
Coloc Hits
FinRegistry
FinnGen
FinRegistry
FinnGen
FinnGen
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