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Viral encephalitis, not elsewhere classified/unspecified

EFO Endpoint Browser PheWeb

AB1_VIRAL_ENCEPHALITIS_NOS

Endpoint definition

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Endpoint definition steps

FinnGen

Phenotype data

473681

1. Apply sex-specific rule

None

473681

2. Check conditions

None

473681

3. Check pre-conditions, main-only, mode, registry filters

Registry filters:

  • Hospital discharge: ICD-10 — A85, A86
  • Hospital discharge: ICD-9 — 06[4]
  • Hospital discharge: ICD-8 — 06[4]
  • Cause of death: ICD-10 — A85, A86
  • Cause of death: ICD-9 — 06[4]
  • Cause of death: ICD-8 — 06[4]

2 out of 7 registries used, show all original rules.

668

4. Check minimum number of events

None

668

5. Include endpoints

None

668

6. Filter based on genotype QC (FinnGen only)

638

Control definitions (FinnGen only)

Control exclude AB1_VIRAL_CNS

Extra metadata

Level in the ICD hierarchy 3
First used in FinnGen datafreeze DF5

Case counts by codes

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FinnGen case counts by registry codes:

generic upset plot

Upset plot

Full data table

Summary Statistics

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-FinRegistry-

Key figures

All Female Male
Number of individuals
Whole population 6491 3070 3393
Only index persons 5729 2699 3030
Unadjusted period prevalence (%)
Whole population 0.09 0.09 0.09
Only index persons 0.11 0.10 0.12
Median age at first event (years)
Whole population 52.94 56.53 49.53
Only index persons 52.07 55.63 48.89

-FinnGen-

Key figures

All Female Male
Number of individuals 638 323 315
Unadjusted period prevalence (%) 0.14 0.13 0.16
Median age at first event (years) 56.88 53.33 60.53

-FinRegistry-

Age distribution of first events

-FinnGen-

Age distribution of first events

-FinRegistry-

Year distribution of first events

-FinnGen-

Year distribution of first events

-FinRegistry-

Cumulative Incidence Function

-FinnGen-

Cumulative Incidence Function

Mortality – FinRegistry

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Association

Association between endpoint AB1_VIRAL_ENCEPHALITIS_NOS and mortality.

Females

Parameter HR [95% CI] p-value
AB1_VIRAL_ENCEPHALITIS_NOS 2.464 [2.09, 2.9] < 0.001
Birth year 0.992 [0.98, 1.0] 0.08

During the follow-up period (1.1.1998 — 31.12.2019), 682 out of 2632 females with AB1_VIRAL_ENCEPHALITIS_NOS died.

Males

Parameter HR [95% CI] p-value
AB1_VIRAL_ENCEPHALITIS_NOS 2.368 [2.0, 2.8] < 0.001
Birth year 0.989 [0.98, 1.0] 0.027

During the follow-up period (1.1.1998 — 31.12.2019), 697 out of 2910 males with AB1_VIRAL_ENCEPHALITIS_NOS died.

Mortality risk

Mortality risk for people of age

years, who have AB1_VIRAL_ENCEPHALITIS_NOS.

N-year risk Females Males
1 0.192% 0.38%
5 1.417% 2.691%
10 3.442% 7.213%
15 6.084% 13.363%
20 10.659% 21.966%

Relationships between endpoints

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Index endpoint: AB1_VIRAL_ENCEPHALITIS_NOS – Viral encephalitis, not elsewhere classified/unspecified

GWS hits: -

Endpoint
Case Overlap
Survival Analysis
Genetic Correlations
Genetic Signals
N (Jaccard index)
HR [CI]
Extremity
rg [CI]
Extremity
Hits
Coloc Hits
FinRegistry
FinnGen
FinRegistry
FinnGen
FinnGen
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