protein energy malnutrition: A nutritional deficit that is caused by inadequate protein or calorie intake.
Endpoint definition
↥
Endpoint definition steps |
FinnGen |
|---|---|
Phenotype data |
473681 |
1. Apply sex-specific ruleNone |
473681 |
2. Check conditionsNone |
473681 |
3. Check pre-conditions, main-only, mode, registry filtersRegistry filters: 2 out of 7 registries used, show all original rules. |
580 |
4. Check minimum number of eventsNone |
580 |
5. Include endpoints |
615 |
6. Filter based on genotype QC (FinnGen only) |
585 |
Control definitions (FinnGen only)
Controls for this endpoint are individuals that are not cases.
Extra metadata
Level in the ICD hierarchy
2
First used in FinnGen datafreeze
DF2
Malnutrition
based on the number of shared cases.
Similar with more cases:
Similar with less cases:
Summary Statistics
↥-FinRegistry-
Key figures
| All | Female | Male | |
|---|---|---|---|
| Number of individuals | |||
| Whole population | 9178 | 5172 | 3965 |
| Only index persons | 7591 | 4380 | 3211 |
| Unadjusted period prevalence (%) | |||
| Whole population | 0.13 | 0.15 | 0.11 |
| Only index persons | 0.14 | 0.16 | 0.12 |
| Median age at first event (years) | |||
| Whole population | 67.39 | 70.70 | 63.06 |
| Only index persons | 68.88 | 71.80 | 64.89 |
-FinnGen-
Key figures
| All | Female | Male | |
|---|---|---|---|
| Number of individuals | 585 | 312 | 273 |
| Unadjusted period prevalence (%) | 0.13 | 0.12 | 0.14 |
| Median age at first event (years) | 63.08 | 60.83 | 65.65 |
-FinRegistry-
Age distribution of first events
-FinnGen-
Age distribution of first events
-FinRegistry-
Year distribution of first events
-FinnGen-
Year distribution of first events
-FinRegistry-
Cumulative Incidence Function
-FinnGen-
Cumulative Incidence Function
Mortality – FinRegistry
↥Association
Association between endpoint E4_MALNUTRITION and mortality.
Females
| Parameter | HR [95% CI] | p-value |
|---|---|---|
| E4_MALNUTRITION | 3.526 [2.72, 4.58] | < 0.001 |
| Birth year | 0.994 [0.99, 1.0] | 0.157 |
During the follow-up period (1.1.1998 — 31.12.2019), 1285 out of 3662 females with E4_MALNUTRITION died.
Males
| Parameter | HR [95% CI] | p-value |
|---|---|---|
| E4_MALNUTRITION | 4.659 [3.32, 6.54] | < 0.001 |
| Birth year | 0.987 [0.98, 1.0] | 0.006 |
During the follow-up period (1.1.1998 — 31.12.2019), 1087 out of 2742 males with E4_MALNUTRITION died.
Mortality risk
Mortality risk for people of age
years, who have E4_MALNUTRITION.| N-year risk | Females | Males |
|---|---|---|
| 1 | 0.257% | 1.008% |
| 5 | 1.853% | 5.19% |
| 10 | 4.843% | 12.782% |
| 15 | 8.936% | 22.768% |
| 20 | 15.271% | 36.475% |
Relationships between endpoints
↥Index endpoint: E4_MALNUTRITION – Malnutrition
GWS hits: -
Endpoint
Case Overlap
Survival Analysis
Genetic Correlations
Genetic Signals
N (Jaccard index)
HR [CI]
Extremity
rg [CI]
Extremity
Hits
Coloc Hits
FinRegistry
FinnGen
FinRegistry
FinnGen
FinnGen
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