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Protein-energy malnutrition of moderate and mild degree

DOID EFO Endpoint Browser PheWeb

E4_PROTMALMODMILD

protein energy malnutrition: A nutritional deficit that is caused by inadequate protein or calorie intake.

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Endpoint definition

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Endpoint definition steps

FinnGen

Phenotype data

473681

1. Apply sex-specific rule

None

473681

2. Check conditions

None

473681

3. Check pre-conditions, main-only, mode, registry filters

Registry filters:

  • Hospital discharge: ICD-10 — E44
  • Hospital discharge: ICD-9 — 263
  • Hospital discharge: excluded ICD-9 — 2632
  • Cause of death: ICD-10 — E44
  • Cause of death: ICD-9 — 263
  • Cause of death: excluded ICD-9 — 2632

2 out of 7 registries used, show all original rules.

247

4. Check minimum number of events

None

247

5. Include endpoints

None

247

6. Filter based on genotype QC (FinnGen only)

233

Control definitions (FinnGen only)

Control exclude E4_MALNUTRITION

Extra metadata

Level in the ICD hierarchy 3
First used in FinnGen datafreeze DF2
Parent code in ICD-10 E40-E46
Name in latin Malnutritio moderata sive levis ex deficientia proteino-energetica

Case counts by codes

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FinnGen case counts by registry codes:

generic upset plot

Upset plot

Full data table

Summary Statistics

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-FinRegistry-

Key figures

All Female Male
Number of individuals
Whole population 3200 1841 1349
Only index persons 2726 1607 1119
Unadjusted period prevalence (%)
Whole population 0.05 0.05 0.04
Only index persons 0.05 0.06 0.04
Median age at first event (years)
Whole population 65.21 68.83 60.28
Only index persons 68.06 71.33 63.35

-FinnGen-

Key figures

All Female Male
Number of individuals 233 125 108
Unadjusted period prevalence (%) 0.05 0.05 0.05
Median age at first event (years) 63.46 61.03 66.27

-FinRegistry-

Age distribution of first events

-FinnGen-

Age distribution of first events

-FinRegistry-

Year distribution of first events

-FinnGen-

Year distribution of first events

-FinRegistry-

Cumulative Incidence Function

-FinnGen-

Cumulative Incidence Function

No data

Mortality – FinRegistry

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Association

Association between endpoint E4_PROTMALMODMILD and mortality.

Females

Parameter HR [95% CI] p-value
E4_PROTMALMODMILD 3.147 [2.18, 4.54] < 0.001
Birth year 0.998 [0.99, 1.01] 0.571

During the follow-up period (1.1.1998 — 31.12.2019), 470 out of 1454 females with E4_PROTMALMODMILD died.

Males

Parameter HR [95% CI] p-value
E4_PROTMALMODMILD 5.396 [3.07, 9.48] < 0.001
Birth year 0.987 [0.98, 1.0] 0.006

During the follow-up period (1.1.1998 — 31.12.2019), 388 out of 1064 males with E4_PROTMALMODMILD died.

Mortality risk

Mortality risk for people of age

years, who have E4_PROTMALMODMILD.

N-year risk Females Males
1 0.371% 1.062%
5 2.039% 5.903%
10 5.263% 14.741%
15 9.564% 25.784%
20 16.165% 39.597%

Relationships between endpoints

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Index endpoint: E4_PROTMALMODMILD – Protein-energy malnutrition of moderate and mild degree

GWS hits: -

Endpoint
Case Overlap
Survival Analysis
Genetic Correlations
Genetic Signals
N (Jaccard index)
HR [CI]
Extremity
rg [CI]
Extremity
Hits
Coloc Hits
FinRegistry
FinnGen
FinRegistry
FinnGen
FinnGen
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