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This is a non-core endpoint: only basic statistics are computed.

See these related core endpoints for full statistics:

Nutritional marasmus

E4_MARASMUS

marasmus: The lack of sufficient energy or protein to meet the body's metabolic demands, as a result of either an inadequate dietary intake of protein, intake of poor quality dietary protein, increased demands due to disease, or increased nutrient losses.

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Endpoint definition

Endpoint definition steps

FinnGen

Phenotype data

473681

1. Apply sex-specific rule

None

473681

2. Check conditions

None

473681

3. Check pre-conditions, main-only, mode, registry filters

Registry filters:

  • Hospital discharge: ICD-10 E41
  • Hospital discharge: ICD-9 261
  • Cause of death: ICD-10 E41
  • Cause of death: ICD-9 261

2 out of 7 registries used, show all original rules.

45

4. Check minimum number of events

None

45

5. Include endpoints

None

45

6. Filter based on genotype QC (FinnGen only)

43

Control definitions (FinnGen only)

Control exclude E4_MALNUTRITION

Extra metadata

Level in the ICD hierarchy 3
First used in FinnGen datafreeze DF2
Parent code in ICD-10 E40-E46
Name in latin Malnutritio gravis ex deficientia energetica (marasmus nutritionalis)

Case counts by codes

FinnGen case counts by registry codes:

generic upset plot

Upset plot

Full data table

Summary Statistics

-FinRegistry-

Key figures

All Female Male
Number of individuals
Whole population 989 547 434
Only index persons 714 397 317
Unadjusted period prevalence (%)
Whole population 0.01 0.02 0.01
Only index persons 0.01 0.01 0.01
Median age at first event (years)
Whole population 63.82 66.09 60.76
Only index persons 59.82 61.49 57.73

-FinnGen-

Key figures

All Female Male
Number of individuals 43 23 20
Unadjusted period prevalence (%) 0.01 0.01 0.01
Median age at first event (years) 52.73 44.21 62.53

-FinRegistry-

Age distribution of first events

-FinnGen-

Age distribution of first events

-FinRegistry-

Year distribution of first events

-FinnGen-

Year distribution of first events

-FinRegistry-

Cumulative Incidence Function

-FinnGen-

Cumulative Incidence Function

Not a core endpoint, no data to show.

Mortality – FinRegistry

Association

Association between endpoint E4_MARASMUS and mortality.

Females

Parameter HR [95% CI] p-value
E4_MARASMUS 5.254 [2.49, 11.07] < 0.001
Birth year 0.996 [0.99, 1.0] 0.322

During the follow-up period (1.1.1998 — 31.12.2019), 120 out of 307 females with E4_MARASMUS died.

Males

Parameter HR [95% CI] p-value
E4_MARASMUS 6.144 [2.76, 13.69] < 0.001
Birth year 0.993 [0.98, 1.0] 0.122

During the follow-up period (1.1.1998 — 31.12.2019), 90 out of 242 males with E4_MARASMUS died.

Mortality risk

Mortality risk for people of age

years, who have E4_MARASMUS.

N-year risk Females Males
1 0.561% 1.389%
5 2.995% 8.042%
10 7.721% 19.488%
15 14.526% 35.354%
20 23.997% 52.914%

Relationships between endpoints

Index endpoint: E4_MARASMUS – Nutritional marasmus

GWS hits: -

Endpoint
Case Overlap
Survival Analysis
Genetic Correlations
Genetic Signals
N (Jaccard index)
HR [CI]
Extremity
rg [CI]
Extremity
Hits
Coloc Hits
FinRegistry
FinnGen
FinRegistry
FinnGen
FinnGen
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