This is a non-core endpoint: only basic statistics are computed.
See these related core endpoints for full statistics:
Nutritional marasmus
E4_MARASMUS
marasmus: The lack of sufficient energy or protein to meet the body's metabolic demands, as a result of either an inadequate dietary intake of protein, intake of poor quality dietary protein, increased demands due to disease, or increased nutrient losses.
Endpoint definition
↥
Endpoint definition steps |
FinnGen |
|---|---|
Phenotype data |
473681 |
1. Apply sex-specific ruleNone |
473681 |
2. Check conditionsNone |
473681 |
3. Check pre-conditions, main-only, mode, registry filtersRegistry filters:
2 out of 7 registries used, show all original rules. |
45 |
4. Check minimum number of eventsNone |
45 |
5. Include endpointsNone |
45 |
6. Filter based on genotype QC (FinnGen only) |
43 |
Control definitions (FinnGen only)
Control exclude
E4_MALNUTRITION
Extra metadata
Level in the ICD hierarchy
3
First used in FinnGen datafreeze
DF2
Parent code in ICD-10
E40-E46
Name in latin
Malnutritio gravis ex deficientia energetica (marasmus nutritionalis)
Similar endpoints
↥List of similar endpoints to
Nutritional marasmus
based on the number of shared cases.
Similar with more cases:
- Malnutrition
- Endocrine, nutritional and metabolic diseases
- Any operation in hilmo
- Any event in hilmo or specialist outpatient
- Any prescribed medicine buy
Similar with less cases:
None
Case counts by codes
↥
Summary Statistics
↥-FinRegistry-
Key figures
| All | Female | Male | |
|---|---|---|---|
| Number of individuals | |||
| Whole population | 989 | 547 | 434 |
| Only index persons | 714 | 397 | 317 |
| Unadjusted period prevalence (%) | |||
| Whole population | 0.01 | 0.02 | 0.01 |
| Only index persons | 0.01 | 0.01 | 0.01 |
| Median age at first event (years) | |||
| Whole population | 63.82 | 66.09 | 60.76 |
| Only index persons | 59.82 | 61.49 | 57.73 |
-FinnGen-
Key figures
| All | Female | Male | |
|---|---|---|---|
| Number of individuals | 43 | 23 | 20 |
| Unadjusted period prevalence (%) | 0.01 | 0.01 | 0.01 |
| Median age at first event (years) | 52.73 | 44.21 | 62.53 |
-FinRegistry-
Age distribution of first events
-FinnGen-
Age distribution of first events
-FinRegistry-
Year distribution of first events
-FinnGen-
Year distribution of first events
-FinRegistry-
Cumulative Incidence Function
-FinnGen-
Cumulative Incidence Function
Not a core endpoint, no data to show.
Mortality – FinRegistry
↥Association
Association between endpoint E4_MARASMUS and mortality.
Females
| Parameter | HR [95% CI] | p-value |
|---|---|---|
| E4_MARASMUS | 5.254 [2.49, 11.07] | < 0.001 |
| Birth year | 0.996 [0.99, 1.0] | 0.322 |
During the follow-up period (1.1.1998 — 31.12.2019), 120 out of 307 females with E4_MARASMUS died.
Males
| Parameter | HR [95% CI] | p-value |
|---|---|---|
| E4_MARASMUS | 6.144 [2.76, 13.69] | < 0.001 |
| Birth year | 0.993 [0.98, 1.0] | 0.122 |
During the follow-up period (1.1.1998 — 31.12.2019), 90 out of 242 males with E4_MARASMUS died.
Mortality risk
Mortality risk for people of age
years, who have E4_MARASMUS.| N-year risk | Females | Males |
|---|---|---|
| 1 | 0.561% | 1.389% |
| 5 | 2.995% | 8.042% |
| 10 | 7.721% | 19.488% |
| 15 | 14.526% | 35.354% |
| 20 | 23.997% | 52.914% |
Relationships between endpoints
↥Index endpoint: E4_MARASMUS – Nutritional marasmus
GWS hits: -
Endpoint
Case Overlap
Survival Analysis
Genetic Correlations
Genetic Signals
N (Jaccard index)
HR [CI]
Extremity
rg [CI]
Extremity
Hits
Coloc Hits
FinRegistry
FinnGen
FinRegistry
FinnGen
FinnGen
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