kwashiorkor: A syndrome produced by severe protein deficiency, characterized by retarded growth, changes in skin and hair pigment, edema, and pathologic changes in the liver, including fatty infiltration, necrosis, and fibrosis. The word is a local name in Gold Coast, Africa, meaning 'displaced child'. Although first reported from Africa, kwashiorkor is now known throughout the world, but mainly in the tropics and subtropics. It is considered to be related to marasmus. (From Dorland, 27th ed)
Endpoint definition
↥
Endpoint definition steps |
FinnGen |
|---|---|
Phenotype data |
473681 |
1. Apply sex-specific ruleNone |
473681 |
2. Check conditionsNone |
473681 |
3. Check pre-conditions, main-only, mode, registry filtersRegistry filters: 2 out of 7 registries used, show all original rules. |
73 |
4. Check minimum number of eventsNone |
73 |
5. Include endpointsNone |
73 |
6. Filter based on genotype QC (FinnGen only) |
71 |
Control definitions (FinnGen only)
Control exclude
E4_MALNUTRITION
Extra metadata
Level in the ICD hierarchy
3
First used in FinnGen datafreeze
DF2
Parent code in ICD-10
E40-E46
Name in latin
Malnutritio gravis ex deficientia proteino-energetica
Similar endpoints
↥List of similar endpoints to
Marasmic kwashiorkor
based on the number of shared cases.
Similar with more cases:
- Malnutrition
- Endocrine, nutritional and metabolic diseases
- Any operation in hilmo
- Any event in hilmo or specialist outpatient
- Any prescribed medicine buy
Similar with less cases:
None
Case counts by codes
↥
Summary Statistics
↥-FinRegistry-
Key figures
| All | Female | Male | |
|---|---|---|---|
| Number of individuals | |||
| Whole population | 1073 | 584 | 487 |
| Only index persons | 804 | 455 | 349 |
| Unadjusted period prevalence (%) | |||
| Whole population | 0.02 | 0.02 | 0.01 |
| Only index persons | 0.02 | 0.02 | 0.01 |
| Median age at first event (years) | |||
| Whole population | 58.77 | 60.88 | 56.20 |
| Only index persons | 62.87 | 64.42 | 60.86 |
-FinnGen-
Key figures
| All | Female | Male | |
|---|---|---|---|
| Number of individuals | 71 | 42 | 29 |
| Unadjusted period prevalence (%) | 0.02 | 0.02 | 0.01 |
| Median age at first event (years) | 55.24 | 52.53 | 59.16 |
-FinRegistry-
Age distribution of first events
-FinnGen-
Age distribution of first events
-FinRegistry-
Year distribution of first events
-FinnGen-
Year distribution of first events
-FinRegistry-
Cumulative Incidence Function
-FinnGen-
Cumulative Incidence Function
No data
Mortality – FinRegistry
↥Association
Association between endpoint E4_MARAKWASH and mortality.
Females
| Parameter | HR [95% CI] | p-value |
|---|---|---|
| E4_MARAKWASH | 5.458 [2.91, 10.24] | < 0.001 |
| Birth year | 0.993 [0.98, 1.0] | 0.121 |
During the follow-up period (1.1.1998 — 31.12.2019), 139 out of 423 females with E4_MARAKWASH died.
Males
| Parameter | HR [95% CI] | p-value |
|---|---|---|
| E4_MARAKWASH | 5.927 [2.85, 12.32] | < 0.001 |
| Birth year | 0.986 [0.98, 1.0] | 0.003 |
During the follow-up period (1.1.1998 — 31.12.2019), 143 out of 376 males with E4_MARAKWASH died.
Mortality risk
Mortality risk for people of age
years, who have E4_MARAKWASH.| N-year risk | Females | Males |
|---|---|---|
| 1 | 0.551% | 1.038% |
| 5 | 3.196% | 6.602% |
| 10 | 7.482% | 16.39% |
| 15 | 14.462% | 28.837% |
| 20 | 23.039% | 44.041% |
Relationships between endpoints
↥Index endpoint: E4_MARAKWASH – Marasmic kwashiorkor
GWS hits: -
Endpoint
Case Overlap
Survival Analysis
Genetic Correlations
Genetic Signals
N (Jaccard index)
HR [CI]
Extremity
rg [CI]
Extremity
Hits
Coloc Hits
FinRegistry
FinnGen
FinRegistry
FinnGen
FinnGen
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