protein energy malnutrition: A nutritional deficit that is caused by inadequate protein or calorie intake.
Endpoint definition
↥
Endpoint definition steps |
FinnGen |
|---|---|
Phenotype data |
473681 |
1. Apply sex-specific ruleNone |
473681 |
2. Check conditionsNone |
473681 |
3. Check pre-conditions, main-only, mode, registry filtersRegistry filters:
2 out of 7 registries used, show all original rules. |
52 |
4. Check minimum number of eventsNone |
52 |
5. Include endpointsNone |
52 |
6. Filter based on genotype QC (FinnGen only) |
51 |
Control definitions (FinnGen only)
Control exclude
E4_MALNUTRITION
Extra metadata
Level in the ICD hierarchy
3
First used in FinnGen datafreeze
DF2
Parent code in ICD-10
E40-E46
Name in latin
Malnutritio gravis non specificata ex deficientia proteino-energetica
Similar endpoints
↥List of similar endpoints to
Unspecified severe protein-energy malnutrition
based on the number of shared cases.
Similar with more cases:
- Malnutrition
- Endocrine, nutritional and metabolic diseases
- Any operation in hilmo
- Any event in hilmo or specialist outpatient
- Any prescribed medicine buy
Similar with less cases:
None
Case counts by codes
↥
Summary Statistics
↥-FinRegistry-
Key figures
| All | Female | Male | |
|---|---|---|---|
| Number of individuals | |||
| Whole population | 626 | 344 | 279 |
| Only index persons | 505 | 279 | 226 |
| Unadjusted period prevalence (%) | |||
| Whole population | 0.01 | 0.01 | 0.01 |
| Only index persons | 0.01 | 0.01 | 0.01 |
| Median age at first event (years) | |||
| Whole population | 64.53 | 67.07 | 61.20 |
| Only index persons | 65.05 | 66.99 | 62.65 |
-FinnGen-
Key figures
| All | Female | Male | |
|---|---|---|---|
| Number of individuals | 51 | 25 | 26 |
| Unadjusted period prevalence (%) | 0.01 | 0.01 | 0.01 |
| Median age at first event (years) | 59.23 | 61.63 | 56.91 |
-FinRegistry-
Age distribution of first events
-FinnGen-
Age distribution of first events
-FinRegistry-
Year distribution of first events
-FinnGen-
Year distribution of first events
-FinRegistry-
Cumulative Incidence Function
-FinnGen-
Cumulative Incidence Function
No data
Mortality – FinRegistry
↥Association
Association between endpoint E4_PROTMALSEVERNAS and mortality.
Females
| Parameter | HR [95% CI] | p-value |
|---|---|---|
| E4_PROTMALSEVERNAS | 3.346 [1.57, 7.12] | 0.002 |
| Birth year | 0.993 [0.98, 1.0] | 0.107 |
During the follow-up period (1.1.1998 — 31.12.2019), 68 out of 201 females with E4_PROTMALSEVERNAS died.
Males
| Parameter | HR [95% CI] | p-value |
|---|---|---|
| E4_PROTMALSEVERNAS | 6.849 [2.06, 22.8] | 0.002 |
| Birth year | 0.987 [0.98, 1.0] | 0.008 |
During the follow-up period (1.1.1998 — 31.12.2019), 64 out of 160 males with E4_PROTMALSEVERNAS died.
Mortality risk
Mortality risk for people of age
years, who have E4_PROTMALSEVERNAS.| N-year risk | Females | Males |
|---|---|---|
| 1 | 0.29% | 1.46% |
| 5 | 1.942% | 8.146% |
| 10 | 5.103% | 19.041% |
| 15 | 9.243% | 33.129% |
| 20 | 15.862% | 49.043% |
Relationships between endpoints
↥Index endpoint: E4_PROTMALSEVERNAS – Unspecified severe protein-energy malnutrition
GWS hits: -
Endpoint
Case Overlap
Survival Analysis
Genetic Correlations
Genetic Signals
N (Jaccard index)
HR [CI]
Extremity
rg [CI]
Extremity
Hits
Coloc Hits
FinRegistry
FinnGen
FinRegistry
FinnGen
FinnGen
Loading data