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Unspecified protein-energy malnutrition

DOID EFO Endpoint Browser PheWeb

E4_PROTMALNAS

protein energy malnutrition: A nutritional deficit that is caused by inadequate protein or calorie intake.

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Endpoint definition

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Endpoint definition steps

FinnGen

Phenotype data

473681

1. Apply sex-specific rule

None

473681

2. Check conditions

None

473681

3. Check pre-conditions, main-only, mode, registry filters

Registry filters:

  • Hospital discharge: ICD-10 — E46
  • Hospital discharge: ICD-9 — 263[8-9]
  • Hospital discharge: ICD-8 — 26799
  • Cause of death: ICD-10 — E46
  • Cause of death: ICD-9 — 263[8-9]
  • Cause of death: ICD-8 — 26799

2 out of 7 registries used, show all original rules.

160

4. Check minimum number of events

None

160

5. Include endpoints

None

160

6. Filter based on genotype QC (FinnGen only)

149

Control definitions (FinnGen only)

Control exclude E4_MALNUTRITION

Extra metadata

Level in the ICD hierarchy 3
First used in FinnGen datafreeze DF2
Parent code in ICD-10 E40-E46
Name in latin Malnutritio non specificata ex deficientia proteino-energetica

Case counts by codes

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FinnGen case counts by registry codes:

generic upset plot

Upset plot

Full data table

Summary Statistics

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-FinRegistry-

Key figures

All Female Male
Number of individuals
Whole population 2837 1661 1166
Only index persons 2520 1510 1010
Unadjusted period prevalence (%)
Whole population 0.04 0.05 0.03
Only index persons 0.05 0.06 0.04
Median age at first event (years)
Whole population 75.04 77.51 71.59
Only index persons 75.85 78.14 72.43

-FinnGen-

Key figures

All Female Male
Number of individuals 149 82 67
Unadjusted period prevalence (%) 0.03 0.03 0.03
Median age at first event (years) 71.78 67.59 76.91

-FinRegistry-

Age distribution of first events

-FinnGen-

Age distribution of first events

-FinRegistry-

Year distribution of first events

-FinnGen-

Year distribution of first events

-FinRegistry-

Cumulative Incidence Function

-FinnGen-

Cumulative Incidence Function

No data

Mortality – FinRegistry

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Association

Association between endpoint E4_PROTMALNAS and mortality.

Females

Parameter HR [95% CI] p-value
E4_PROTMALNAS 2.983 [1.98, 4.5] < 0.001
Birth year 0.999 [0.99, 1.01] 0.849

During the follow-up period (1.1.1998 — 31.12.2019), 423 out of 1180 females with E4_PROTMALNAS died.

Males

Parameter HR [95% CI] p-value
E4_PROTMALNAS 4.251 [2.36, 7.66] < 0.001
Birth year 0.993 [0.98, 1.0] 0.108

During the follow-up period (1.1.1998 — 31.12.2019), 339 out of 773 males with E4_PROTMALNAS died.

Mortality risk

Mortality risk for people of age

years, who have E4_PROTMALNAS.

N-year risk Females Males
1 0.239% 1.022%
5 1.836% 5.449%
10 5.126% 13.589%
15 9.269% 24.479%
20 16.303% 39.043%

Relationships between endpoints

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Index endpoint: E4_PROTMALNAS – Unspecified protein-energy malnutrition

GWS hits: -

Endpoint
Case Overlap
Survival Analysis
Genetic Correlations
Genetic Signals
N (Jaccard index)
HR [CI]
Extremity
rg [CI]
Extremity
Hits
Coloc Hits
FinRegistry
FinnGen
FinRegistry
FinnGen
FinnGen
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