vestibular disease: Pathological processes of the vestibular labyrinth which contains part of the balancing apparatus. Patients with vestibular diseases show instability and are at risk of frequent falls. [database_cross_reference: MESH:D015837]
Endpoint definition
↥
Endpoint definition steps |
FinnGen |
|---|---|
Phenotype data |
473681 |
1. Apply sex-specific ruleNone |
473681 |
2. Check conditionsNone |
473681 |
3. Check pre-conditions, main-only, mode, registry filtersNone 0 out of 7 registries used, show all original rules. |
0 |
4. Check minimum number of eventsNone |
0 |
5. Include endpoints |
19408 |
6. Filter based on genotype QC (FinnGen only) |
18693 |
Control definitions (FinnGen only)
Control exclude
H8_INNER
Extra metadata
Level in the ICD hierarchy
3
First used in FinnGen datafreeze
DF2
Similar endpoints
↥List of similar endpoints to
Disorders of vestibular function (Vertigo)
based on the number of shared cases.
Similar with more cases:
- Diseases of inner ear
- Diseases of the ear and mastoid process
- Any event in hilmo or specialist outpatient
Similar with less cases:
Case counts by codes
↥
Summary Statistics
↥-FinRegistry-
Key figures
| All | Female | Male | |
|---|---|---|---|
| Number of individuals | |||
| Whole population | 151337 | 96975 | 53628 |
| Only index persons | 142559 | 92295 | 50264 |
| Unadjusted period prevalence (%) | |||
| Whole population | 2.31 | 2.78 | 1.50 |
| Only index persons | 2.87 | 3.39 | 1.92 |
| Median age at first event (years) | |||
| Whole population | 60.65 | 61.48 | 59.30 |
| Only index persons | 60.10 | 60.84 | 58.76 |
-FinnGen-
Key figures
| All | Female | Male | |
|---|---|---|---|
| Number of individuals | 18693 | 12161 | 6532 |
| Unadjusted period prevalence (%) | 4.25 | 4.78 | 3.28 |
| Median age at first event (years) | 59.25 | 58.08 | 61.42 |
-FinRegistry-
Age distribution of first events
-FinnGen-
Age distribution of first events
-FinRegistry-
Year distribution of first events
-FinnGen-
Year distribution of first events
-FinRegistry-
Cumulative Incidence Function
-FinnGen-
Cumulative Incidence Function
Mortality – FinRegistry
↥Association
Association between endpoint H8_VERTIGO and mortality.
Females
| Parameter | HR [95% CI] | p-value |
|---|---|---|
| H8_VERTIGO | 0.858 [0.79, 0.93] | < 0.001 |
| Birth year | 0.994 [0.99, 1.0] | 0.117 |
During the follow-up period (1.1.1998 — 31.12.2019), 12231 out of 78185 females with H8_VERTIGO died.
Males
| Parameter | HR [95% CI] | p-value |
|---|---|---|
| H8_VERTIGO | 0.837 [0.77, 0.91] | < 0.001 |
| Birth year | 0.987 [0.98, 1.0] | 0.006 |
During the follow-up period (1.1.1998 — 31.12.2019), 7545 out of 42683 males with H8_VERTIGO died.
Mortality risk
Mortality risk for people of age
years, who have H8_VERTIGO.| N-year risk | Females | Males |
|---|---|---|
| 1 | 0.069% | 0.167% |
| 5 | 0.499% | 1.018% |
| 10 | 1.215% | 2.443% |
| 15 | 2.218% | 4.685% |
| 20 | 4.018% | 8.167% |
Relationships between endpoints
↥Index endpoint: H8_VERTIGO – Disorders of vestibular function (Vertigo)
GWS hits: 3
Endpoint
Case Overlap
Survival Analysis
Genetic Correlations
Genetic Signals
N (Jaccard index)
HR [CI]
Extremity
rg [CI]
Extremity
Hits
Coloc Hits
FinRegistry
FinnGen
FinRegistry
FinnGen
FinnGen
Loading data