Other peripheral vertigo

H8_PERIPHVERTIGO

Endpoint definition

Endpoint definition steps

FinnGen

Phenotype data

473681

1. Apply sex-specific rule

None

473681

2. Check conditions

None

473681

3. Check pre-conditions, main-only, mode, registry filters

Registry filters:

  • Hospital discharge: ICD-10 H81.3
  • Cause of death: ICD-10 H81.3

2 out of 7 registries used, show all original rules.

3166

4. Check minimum number of events

None

3166

5. Include endpoints

None

3166

6. Filter based on genotype QC (FinnGen only)

3060

Control definitions (FinnGen only)

Control exclude H8_INNER

Extra metadata

Level in the ICD hierarchy 4
First used in FinnGen datafreeze DF2
Parent code in ICD-10 H81
Name in latin Alia vertigo peripherica

Case counts by codes

FinnGen case counts by registry codes:

generic upset plot

Upset plot

Full data table

Summary Statistics

-FinRegistry-

Key figures

All Female Male
Number of individuals
Whole population 22431 14326 8009
Only index persons 21331 13746 7585
Unadjusted period prevalence (%)
Whole population 0.34 0.41 0.22
Only index persons 0.43 0.51 0.29
Median age at first event (years)
Whole population 59.92 60.67 58.74
Only index persons 59.30 59.97 58.08

-FinnGen-

Key figures

All Female Male
Number of individuals 3060 1975 1085
Unadjusted period prevalence (%) 0.69 0.78 0.54
Median age at first event (years) 58.25 56.77 60.94

-FinRegistry-

Age distribution of first events

-FinnGen-

Age distribution of first events

-FinRegistry-

Year distribution of first events

-FinnGen-

Year distribution of first events

-FinRegistry-

Cumulative Incidence Function

-FinnGen-

Cumulative Incidence Function

Mortality – FinRegistry

Association

Association between endpoint H8_PERIPHVERTIGO and mortality.

Females

Parameter HR [95% CI] p-value
H8_PERIPHVERTIGO 0.894 [0.82, 0.97] 0.011
Birth year 0.99 [0.98, 1.0] 0.021

During the follow-up period (1.1.1998 — 31.12.2019), 2271 out of 12753 females with H8_PERIPHVERTIGO died.

Males

Parameter HR [95% CI] p-value
H8_PERIPHVERTIGO 0.862 [0.78, 0.95] 0.003
Birth year 0.985 [0.98, 0.99] 0.002

During the follow-up period (1.1.1998 — 31.12.2019), 1428 out of 7125 males with H8_PERIPHVERTIGO died.

Mortality risk

Mortality risk for people of age

years, who have H8_PERIPHVERTIGO.

N-year risk Females Males
1 0.056% 0.167%
5 0.442% 1.004%
10 1.156% 2.399%
15 2.051% 4.41%
20 3.659% 7.397%

Relationships between endpoints

Index endpoint: H8_PERIPHVERTIGO – Other peripheral vertigo

GWS hits: 1

Endpoint
Case Overlap
Survival Analysis
Genetic Correlations
Genetic Signals
N (Jaccard index)
HR [CI]
Extremity
rg [CI]
Extremity
Hits
Coloc Hits
FinRegistry
FinnGen
FinRegistry
FinnGen
FinnGen
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