vestibular disease: Pathological processes of the vestibular labyrinth which contains part of the balancing apparatus. Patients with vestibular diseases show instability and are at risk of frequent falls. [database_cross_reference: MESH:D015837]
Endpoint definition
↥
Endpoint definition steps |
FinnGen |
|---|---|
Phenotype data |
473681 |
1. Apply sex-specific ruleNone |
473681 |
2. Check conditionsNone |
473681 |
3. Check pre-conditions, main-only, mode, registry filtersRegistry filters:
2 out of 7 registries used, show all original rules. |
1220 |
4. Check minimum number of eventsNone |
1220 |
5. Include endpointsNone |
1220 |
6. Filter based on genotype QC (FinnGen only) |
1153 |
Control definitions (FinnGen only)
Control exclude
H8_INNER
Extra metadata
Level in the ICD hierarchy
4
First used in FinnGen datafreeze
DF2
Similar endpoints
↥List of similar endpoints to
Other/unspecified disorders of vestibular function
based on the number of shared cases.
Similar with more cases:
- Disorders of vestibular function (Vertigo)
- Diseases of inner ear
- Diseases of the ear and mastoid process
- Any event in hilmo or specialist outpatient
- Any prescribed medicine buy
Similar with less cases:
None
Case counts by codes
↥
Summary Statistics
↥-FinRegistry-
Key figures
| All | Female | Male | |
|---|---|---|---|
| Number of individuals | |||
| Whole population | 10780 | 6802 | 3882 |
| Only index persons | 9261 | 5920 | 3341 |
| Unadjusted period prevalence (%) | |||
| Whole population | 0.16 | 0.19 | 0.11 |
| Only index persons | 0.19 | 0.22 | 0.13 |
| Median age at first event (years) | |||
| Whole population | 64.51 | 66.08 | 61.73 |
| Only index persons | 62.36 | 63.66 | 60.06 |
-FinnGen-
Key figures
| All | Female | Male | |
|---|---|---|---|
| Number of individuals | 1153 | 715 | 438 |
| Unadjusted period prevalence (%) | 0.26 | 0.28 | 0.22 |
| Median age at first event (years) | 60.43 | 59.82 | 61.42 |
-FinRegistry-
Age distribution of first events
-FinnGen-
Age distribution of first events
-FinRegistry-
Year distribution of first events
-FinnGen-
Year distribution of first events
-FinRegistry-
Cumulative Incidence Function
-FinnGen-
Cumulative Incidence Function
Mortality – FinRegistry
↥Association
Association between endpoint H8_VESTIFUNCNAS and mortality.
Females
| Parameter | HR [95% CI] | p-value |
|---|---|---|
| H8_VESTIFUNCNAS | 1.017 [0.9, 1.14] | 0.778 |
| Birth year | 0.994 [0.99, 1.0] | 0.148 |
During the follow-up period (1.1.1998 — 31.12.2019), 998 out of 4177 females with H8_VESTIFUNCNAS died.
Males
| Parameter | HR [95% CI] | p-value |
|---|---|---|
| H8_VESTIFUNCNAS | 1.072 [0.92, 1.25] | 0.379 |
| Birth year | 0.988 [0.98, 1.0] | 0.018 |
During the follow-up period (1.1.1998 — 31.12.2019), 515 out of 2384 males with H8_VESTIFUNCNAS died.
Mortality risk
Mortality risk for people of age
years, who have H8_VESTIFUNCNAS.| N-year risk | Females | Males |
|---|---|---|
| 1 | 0.075% | 0.234% |
| 5 | 0.553% | 1.328% |
| 10 | 1.479% | 3.317% |
| 15 | 2.903% | 6.326% |
| 20 | 4.988% | 10.675% |
Relationships between endpoints
↥Index endpoint: H8_VESTIFUNCNAS – Other/unspecified disorders of vestibular function
GWS hits: -
Endpoint
Case Overlap
Survival Analysis
Genetic Correlations
Genetic Signals
N (Jaccard index)
HR [CI]
Extremity
rg [CI]
Extremity
Hits
Coloc Hits
FinRegistry
FinnGen
FinRegistry
FinnGen
FinnGen
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