endolymphatic hydrops: An accumulation of endolymph in the inner ear (labyrinth) leading to buildup of pressure and distortion of intralabyrinthine structures, such as cochlea and semicircular canals. It is characterized by sensorineural hearing loss; tinnitus; and sometimes vertigo.
Endpoint definition
↥
Endpoint definition steps |
FinnGen |
|---|---|
Phenotype data |
473681 |
1. Apply sex-specific ruleNone |
473681 |
2. Check conditionsNone |
473681 |
3. Check pre-conditions, main-only, mode, registry filtersRegistry filters:
2 out of 7 registries used, show all original rules. |
3413 |
4. Check minimum number of eventsNone |
3413 |
5. Include endpointsNone |
3413 |
6. Filter based on genotype QC (FinnGen only) |
3312 |
Control definitions (FinnGen only)
Control exclude
H8_INNER
Extra metadata
Level in the ICD hierarchy
4
First used in FinnGen datafreeze
DF2
Parent code in ICD-10
H81
Name in latin
Morbus Ménière
Similar endpoints
↥List of similar endpoints to
Ménière disease
based on the number of shared cases.
Similar with more cases:
- Disorders of vestibular function (Vertigo)
- Diseases of inner ear
- Diseases of the ear and mastoid process
- Any event in hilmo or specialist outpatient
Similar with less cases:
None
Case counts by codes
↥
Summary Statistics
↥-FinRegistry-
Key figures
| All | Female | Male | |
|---|---|---|---|
| Number of individuals | |||
| Whole population | 26706 | 17134 | 9455 |
| Only index persons | 24436 | 15945 | 8491 |
| Unadjusted period prevalence (%) | |||
| Whole population | 0.41 | 0.49 | 0.26 |
| Only index persons | 0.50 | 0.59 | 0.32 |
| Median age at first event (years) | |||
| Whole population | 57.15 | 57.45 | 56.61 |
| Only index persons | 56.64 | 56.87 | 56.19 |
-FinnGen-
Key figures
| All | Female | Male | |
|---|---|---|---|
| Number of individuals | 3312 | 2163 | 1149 |
| Unadjusted period prevalence (%) | 0.75 | 0.85 | 0.58 |
| Median age at first event (years) | 55.55 | 54.50 | 57.53 |
-FinRegistry-
Age distribution of first events
-FinnGen-
Age distribution of first events
-FinRegistry-
Year distribution of first events
-FinnGen-
Year distribution of first events
-FinRegistry-
Cumulative Incidence Function
-FinnGen-
Cumulative Incidence Function
Mortality – FinRegistry
↥Association
Association between endpoint H8_MENIERE and mortality.
Females
| Parameter | HR [95% CI] | p-value |
|---|---|---|
| H8_MENIERE | 0.876 [0.8, 0.96] | 0.006 |
| Birth year | 0.991 [0.98, 1.0] | 0.033 |
During the follow-up period (1.1.1998 — 31.12.2019), 1902 out of 13148 females with H8_MENIERE died.
Males
| Parameter | HR [95% CI] | p-value |
|---|---|---|
| H8_MENIERE | 0.777 [0.71, 0.85] | < 0.001 |
| Birth year | 0.988 [0.98, 1.0] | 0.01 |
During the follow-up period (1.1.1998 — 31.12.2019), 1269 out of 7015 males with H8_MENIERE died.
Mortality risk
Mortality risk for people of age
years, who have H8_MENIERE.| N-year risk | Females | Males |
|---|---|---|
| 1 | 0.092% | 0.158% |
| 5 | 0.431% | 0.937% |
| 10 | 1.069% | 2.318% |
| 15 | 2.118% | 4.412% |
| 20 | 3.919% | 7.457% |
Relationships between endpoints
↥Index endpoint: H8_MENIERE – Ménière disease
GWS hits: 2
Endpoint
Case Overlap
Survival Analysis
Genetic Correlations
Genetic Signals
N (Jaccard index)
HR [CI]
Extremity
rg [CI]
Extremity
Hits
Coloc Hits
FinRegistry
FinnGen
FinRegistry
FinnGen
FinnGen
Loading data