vestibular neuronitis: Idiopathic inflammation of the vestibular nerve, characterized clinically by the acute or subacute onset of vertigo; nausea; and imbalance. The cochlear nerve is typically spared and hearing loss and tinnitus do not usually occur. Symptoms usually resolve over a period of days to weeks. (Adams et al., Principles of Neurology, 6th ed, p304)
Endpoint definition
↥
Endpoint definition steps |
FinnGen |
|---|---|
Phenotype data |
473681 |
1. Apply sex-specific ruleNone |
473681 |
2. Check conditionsNone |
473681 |
3. Check pre-conditions, main-only, mode, registry filtersRegistry filters:
2 out of 7 registries used, show all original rules. |
3053 |
4. Check minimum number of eventsNone |
3053 |
5. Include endpointsNone |
3053 |
6. Filter based on genotype QC (FinnGen only) |
2951 |
Control definitions (FinnGen only)
Control exclude
H8_INNER
Extra metadata
Level in the ICD hierarchy
4
First used in FinnGen datafreeze
DF2
Parent code in ICD-10
H81
Name in latin
Neuronitis vestibularis
Similar endpoints
↥List of similar endpoints to
Vestibular neuronitis
based on the number of shared cases.
Similar with more cases:
- Disorders of vestibular function (Vertigo)
- Diseases of inner ear
- Diseases of the ear and mastoid process
- Any event in hilmo or specialist outpatient
Similar with less cases:
None
Case counts by codes
↥
Summary Statistics
↥-FinRegistry-
Key figures
| All | Female | Male | |
|---|---|---|---|
| Number of individuals | |||
| Whole population | 24109 | 13022 | 10994 |
| Only index persons | 22996 | 12504 | 10492 |
| Unadjusted period prevalence (%) | |||
| Whole population | 0.34 | 0.37 | 0.31 |
| Only index persons | 0.43 | 0.46 | 0.40 |
| Median age at first event (years) | |||
| Whole population | 55.00 | 55.56 | 54.40 |
| Only index persons | 54.48 | 54.96 | 53.91 |
-FinnGen-
Key figures
| All | Female | Male | |
|---|---|---|---|
| Number of individuals | 2951 | 1651 | 1300 |
| Unadjusted period prevalence (%) | 0.65 | 0.65 | 0.65 |
| Median age at first event (years) | 55.09 | 53.55 | 57.05 |
-FinRegistry-
Age distribution of first events
-FinnGen-
Age distribution of first events
-FinRegistry-
Year distribution of first events
-FinnGen-
Year distribution of first events
-FinRegistry-
Cumulative Incidence Function
-FinnGen-
Cumulative Incidence Function
Mortality – FinRegistry
↥Association
Association between endpoint H8_VESTIBNEUR and mortality.
Females
| Parameter | HR [95% CI] | p-value |
|---|---|---|
| H8_VESTIBNEUR | 0.785 [0.71, 0.87] | < 0.001 |
| Birth year | 0.997 [0.99, 1.01] | 0.546 |
During the follow-up period (1.1.1998 — 31.12.2019), 927 out of 9696 females with H8_VESTIBNEUR died.
Males
| Parameter | HR [95% CI] | p-value |
|---|---|---|
| H8_VESTIBNEUR | 0.686 [0.61, 0.77] | < 0.001 |
| Birth year | 0.988 [0.98, 1.0] | 0.009 |
During the follow-up period (1.1.1998 — 31.12.2019), 874 out of 8342 males with H8_VESTIBNEUR died.
Mortality risk
Mortality risk for people of age
years, who have H8_VESTIBNEUR.| N-year risk | Females | Males |
|---|---|---|
| 1 | 0.077% | 0.117% |
| 5 | 0.463% | 0.769% |
| 10 | 1.285% | 1.988% |
| 15 | 2.53% | 3.927% |
| 20 | 4.332% | 6.882% |
Relationships between endpoints
↥Index endpoint: H8_VESTIBNEUR – Vestibular neuronitis
GWS hits: 2
Endpoint
Case Overlap
Survival Analysis
Genetic Correlations
Genetic Signals
N (Jaccard index)
HR [CI]
Extremity
rg [CI]
Extremity
Hits
Coloc Hits
FinRegistry
FinnGen
FinRegistry
FinnGen
FinnGen
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