Benign paroxysmal vertigo

H8_BPV

Endpoint definition

Endpoint definition steps

FinnGen

Phenotype data

473681

1. Apply sex-specific rule

None

473681

2. Check conditions

None

473681

3. Check pre-conditions, main-only, mode, registry filters

Registry filters:

  • Hospital discharge: ICD-10 H81.1
  • Cause of death: ICD-10 H81.1

2 out of 7 registries used, show all original rules.

10974

4. Check minimum number of events

None

10974

5. Include endpoints

None

10974

6. Filter based on genotype QC (FinnGen only)

10553

Control definitions (FinnGen only)

Control exclude H8_INNER

Extra metadata

Level in the ICD hierarchy 4
First used in FinnGen datafreeze DF2
Parent code in ICD-10 H81
Name in latin Vertigo paroxysmalis benigna

Case counts by codes

FinnGen case counts by registry codes:

generic upset plot

Upset plot

Full data table

Summary Statistics

-FinRegistry-

Key figures

All Female Male
Number of individuals
Whole population 81636 55245 26044
Only index persons 79327 54067 25260
Unadjusted period prevalence (%)
Whole population 1.30 1.58 0.73
Only index persons 1.66 1.99 0.96
Median age at first event (years)
Whole population 63.55 64.08 62.69
Only index persons 63.40 63.85 62.43

-FinnGen-

Key figures

All Female Male
Number of individuals 10553 7218 3335
Unadjusted period prevalence (%) 2.47 2.83 1.67
Median age at first event (years) 62.18 60.95 64.83

-FinRegistry-

Age distribution of first events

-FinnGen-

Age distribution of first events

-FinRegistry-

Year distribution of first events

-FinnGen-

Year distribution of first events

-FinRegistry-

Cumulative Incidence Function

-FinnGen-

Cumulative Incidence Function

Mortality – FinRegistry

Association

Association between endpoint H8_BPV and mortality.

Females

Parameter HR [95% CI] p-value
H8_BPV 0.808 [0.74, 0.88] < 0.001
Birth year 0.999 [0.99, 1.01] 0.715

During the follow-up period (1.1.1998 — 31.12.2019), 6652 out of 46886 females with H8_BPV died.

Males

Parameter HR [95% CI] p-value
H8_BPV 0.853 [0.77, 0.95] 0.003
Birth year 0.986 [0.98, 0.99] 0.002

During the follow-up period (1.1.1998 — 31.12.2019), 3716 out of 22016 males with H8_BPV died.

Mortality risk

Mortality risk for people of age

years, who have H8_BPV.

N-year risk Females Males
1 0.062% 0.183%
5 0.467% 1.021%
10 1.242% 2.423%
15 2.532% 4.645%
20 4.659% 7.904%

Relationships between endpoints

Index endpoint: H8_BPV – Benign paroxysmal vertigo

GWS hits: 4

Endpoint
Case Overlap
Survival Analysis
Genetic Correlations
Genetic Signals
N (Jaccard index)
HR [CI]
Extremity
rg [CI]
Extremity
Hits
Coloc Hits
FinRegistry
FinnGen
FinRegistry
FinnGen
FinnGen
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