eye disease: A non-neoplastic or neoplastic disorder that affects the eye. Representative examples include conjunctivitis, glaucoma, cataract, conjunctival squamous cell carcinoma, uveal melanoma, and retinoblastoma. [NCIt:C26767]
Endpoint definition
↥
Endpoint definition steps |
FinnGen |
|---|---|
Phenotype data |
473681 |
1. Apply sex-specific ruleNone |
473681 |
2. Check conditionsNone |
473681 |
3. Check pre-conditions, main-only, mode, registry filtersNone 0 out of 7 registries used, show all original rules. |
0 |
4. Check minimum number of eventsNone |
0 |
5. Include endpoints |
812 |
6. Filter based on genotype QC (FinnGen only) |
789 |
Control definitions (FinnGen only)
Control exclude
H7_VITREOUS
Extra metadata
Level in the ICD hierarchy
3
First used in FinnGen datafreeze
DF2
Similar endpoints
↥List of similar endpoints to
Disorders of globe
based on the number of shared cases.
Similar with more cases:
- Disorders of vitreous body and globe
- Diseases of the eye and adnexa
- Any event in hilmo or specialist outpatient
Similar with less cases:
Case counts by codes
↥
Summary Statistics
↥-FinRegistry-
Key figures
| All | Female | Male | |
|---|---|---|---|
| Number of individuals | |||
| Whole population | 9948 | 5247 | 4600 |
| Only index persons | 7619 | 4160 | 3459 |
| Unadjusted period prevalence (%) | |||
| Whole population | 0.14 | 0.15 | 0.13 |
| Only index persons | 0.14 | 0.15 | 0.13 |
| Median age at first event (years) | |||
| Whole population | 66.32 | 70.47 | 61.57 |
| Only index persons | 63.06 | 68.34 | 56.71 |
-FinnGen-
Key figures
| All | Female | Male | |
|---|---|---|---|
| Number of individuals | 789 | 414 | 375 |
| Unadjusted period prevalence (%) | 0.17 | 0.16 | 0.19 |
| Median age at first event (years) | 61.56 | 61.02 | 62.15 |
-FinRegistry-
Age distribution of first events
-FinnGen-
Age distribution of first events
-FinRegistry-
Year distribution of first events
-FinnGen-
Year distribution of first events
-FinRegistry-
Cumulative Incidence Function
-FinnGen-
Cumulative Incidence Function
Mortality – FinRegistry
↥Association
Association between endpoint H7_GLOBE and mortality.
Females
| Parameter | HR [95% CI] | p-value |
|---|---|---|
| H7_GLOBE | 1.188 [1.07, 1.32] | 0.002 |
| Birth year | 0.998 [0.99, 1.01] | 0.557 |
During the follow-up period (1.1.1998 — 31.12.2019), 1511 out of 3733 females with H7_GLOBE died.
Males
| Parameter | HR [95% CI] | p-value |
|---|---|---|
| H7_GLOBE | 1.391 [1.21, 1.59] | < 0.001 |
| Birth year | 0.99 [0.98, 1.0] | 0.047 |
During the follow-up period (1.1.1998 — 31.12.2019), 1101 out of 2981 males with H7_GLOBE died.
Mortality risk
Mortality risk for people of age
years, who have H7_GLOBE.| N-year risk | Females | Males |
|---|---|---|
| 1 | 0.145% | 0.279% |
| 5 | 0.882% | 1.903% |
| 10 | 1.939% | 4.507% |
| 15 | 3.542% | 8.496% |
| 20 | 6.097% | 13.929% |
Relationships between endpoints
↥Index endpoint: H7_GLOBE – Disorders of globe
GWS hits: -
Endpoint
Case Overlap
Survival Analysis
Genetic Correlations
Genetic Signals
N (Jaccard index)
HR [CI]
Extremity
rg [CI]
Extremity
Hits
Coloc Hits
FinRegistry
FinnGen
FinRegistry
FinnGen
FinnGen
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