Other and unspecified disorders of globe

H7_GLOBENAS

eye disease: A non-neoplastic or neoplastic disorder that affects the eye. Representative examples include conjunctivitis, glaucoma, cataract, conjunctival squamous cell carcinoma, uveal melanoma, and retinoblastoma. [NCIt:C26767]

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Endpoint definition

Endpoint definition steps

FinnGen

Phenotype data

473681

1. Apply sex-specific rule

None

473681

2. Check conditions

None

473681

3. Check pre-conditions, main-only, mode, registry filters

Registry filters:

  • Hospital discharge: ICD-10 H44.8, H44.9
  • Hospital discharge: ICD-9 360[8-9]
  • Cause of death: ICD-10 H44.8, H44.9
  • Cause of death: ICD-9 360[8-9]

2 out of 7 registries used, show all original rules.

61

4. Check minimum number of events

None

61

5. Include endpoints

None

61

6. Filter based on genotype QC (FinnGen only)

58

Control definitions (FinnGen only)

Control exclude H7_VITREOUS

Extra metadata

Level in the ICD hierarchy 4
First used in FinnGen datafreeze DF2

Case counts by codes

FinnGen case counts by registry codes:

generic upset plot

Upset plot

Full data table

Summary Statistics

-FinRegistry-

Key figures

All Female Male
Number of individuals
Whole population 657 254 394
Only index persons 443 195 248
Unadjusted period prevalence (%)
Whole population 0.01 0.01 0.01
Only index persons 0.01 0.01 0.01
Median age at first event (years)
Whole population 63.29 62.09 63.90
Only index persons 54.96 56.97 53.37

-FinnGen-

Key figures

All Female Male
Number of individuals 58 28 30
Unadjusted period prevalence (%) 0.01 0.01 0.02
Median age at first event (years) 58.78 52.56 64.59

-FinRegistry-

Age distribution of first events

-FinnGen-

Age distribution of first events

-FinRegistry-

Year distribution of first events

-FinnGen-

Year distribution of first events

-FinRegistry-

Cumulative Incidence Function

No data

-FinnGen-

Cumulative Incidence Function

No data

Mortality – FinRegistry

Association

Association between endpoint H7_GLOBENAS and mortality.

Females

No data

Males

Parameter HR [95% CI] p-value
H7_GLOBENAS 1.845 [1.24, 2.76] 0.003
Birth year 0.986 [0.98, 1.0] 0.005

During the follow-up period (1.1.1998 — 31.12.2019), 71 out of 175 males with H7_GLOBENAS died.

Mortality risk

Mortality risk for people of age

years, who have H7_GLOBENAS.

N-year risk Females Males
1 No data 0.327%
5 No data 1.96%
10 No data 5.069%
15 No data 9.458%
20 No data 15.972%

Relationships between endpoints

Index endpoint: H7_GLOBENAS – Other and unspecified disorders of globe

GWS hits: -

Endpoint
Case Overlap
Survival Analysis
Genetic Correlations
Genetic Signals
N (Jaccard index)
HR [CI]
Extremity
rg [CI]
Extremity
Hits
Coloc Hits
FinRegistry
FinnGen
FinRegistry
FinnGen
FinnGen
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