pathological myopia: ['Excessive axial myopia associated with complications (especially posterior staphyloma and CHOROIDAL NEOVASCULARIZATION) that can lead to BLINDNESS.']
Endpoint definition
↥
Endpoint definition steps |
FinnGen |
|---|---|
Phenotype data |
473681 |
1. Apply sex-specific ruleNone |
473681 |
2. Check conditionsNone |
473681 |
3. Check pre-conditions, main-only, mode, registry filtersRegistry filters:
2 out of 7 registries used, show all original rules. |
209 |
4. Check minimum number of eventsNone |
209 |
5. Include endpointsNone |
209 |
6. Filter based on genotype QC (FinnGen only) |
200 |
Control definitions (FinnGen only)
Control exclude
H7_VITREOUS
Extra metadata
Level in the ICD hierarchy
4
First used in FinnGen datafreeze
DF2
Parent code in ICD-10
H44
Name in latin
Myopia degenerativa
Similar endpoints
↥List of similar endpoints to
Degenerative myopia
based on the number of shared cases.
Similar with more cases:
- Disorders of globe
- Disorders of vitreous body and globe
- Diseases of the eye and adnexa
- Any event in hilmo or specialist outpatient
- Any prescribed medicine buy
Similar with less cases:
None
Case counts by codes
↥
Summary Statistics
↥-FinRegistry-
Key figures
| All | Female | Male | |
|---|---|---|---|
| Number of individuals | |||
| Whole population | 2133 | 1513 | 608 |
| Only index persons | 1912 | 1363 | 549 |
| Unadjusted period prevalence (%) | |||
| Whole population | 0.04 | 0.04 | 0.02 |
| Only index persons | 0.04 | 0.05 | 0.02 |
| Median age at first event (years) | |||
| Whole population | 59.30 | 62.03 | 52.35 |
| Only index persons | 57.27 | 59.91 | 50.71 |
-FinnGen-
Key figures
| All | Female | Male | |
|---|---|---|---|
| Number of individuals | 200 | 150 | 50 |
| Unadjusted period prevalence (%) | 0.05 | 0.06 | 0.03 |
| Median age at first event (years) | 56.95 | 56.74 | 57.56 |
-FinRegistry-
Age distribution of first events
-FinnGen-
Age distribution of first events
-FinRegistry-
Year distribution of first events
-FinnGen-
Year distribution of first events
-FinRegistry-
Cumulative Incidence Function
-FinnGen-
Cumulative Incidence Function
No data
Mortality – FinRegistry
↥Association
Association between endpoint H7_DEGENMYOPIA and mortality.
Females
| Parameter | HR [95% CI] | p-value |
|---|---|---|
| H7_DEGENMYOPIA | 0.986 [0.85, 1.15] | 0.861 |
| Birth year | 0.991 [0.98, 1.0] | 0.057 |
During the follow-up period (1.1.1998 — 31.12.2019), 268 out of 1168 females with H7_DEGENMYOPIA died.
Males
| Parameter | HR [95% CI] | p-value |
|---|---|---|
| H7_DEGENMYOPIA | 0.96 [0.72, 1.27] | 0.776 |
| Birth year | 0.983 [0.97, 0.99] | < 0.001 |
During the follow-up period (1.1.1998 — 31.12.2019), 79 out of 478 males with H7_DEGENMYOPIA died.
Mortality risk
Mortality risk for people of age
years, who have H7_DEGENMYOPIA.| N-year risk | Females | Males |
|---|---|---|
| 1 | 0.071% | 0.19% |
| 5 | 0.463% | 1.034% |
| 10 | 1.237% | 2.553% |
| 15 | 2.487% | 4.715% |
| 20 | 4.421% | 8.143% |
Relationships between endpoints
↥Index endpoint: H7_DEGENMYOPIA – Degenerative myopia
GWS hits: -
Endpoint
Case Overlap
Survival Analysis
Genetic Correlations
Genetic Signals
N (Jaccard index)
HR [CI]
Extremity
rg [CI]
Extremity
Hits
Coloc Hits
FinRegistry
FinnGen
FinRegistry
FinnGen
FinnGen
Loading data