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Purulent endophthalmitis

DOID EFO Endpoint Browser PheWeb

H7_PURENDOPHTHALMITIS

Endpoint definition

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Endpoint definition steps

FinnGen

Phenotype data

473681

1. Apply sex-specific rule

None

473681

2. Check conditions

None

473681

3. Check pre-conditions, main-only, mode, registry filters

Registry filters:

  • Hospital discharge: ICD-10 — H44.0
  • Hospital discharge: ICD-9 — 3600A
  • Hospital discharge: ICD-8 — 3660[0-1]
  • Cause of death: ICD-10 — H44.0
  • Cause of death: ICD-9 — 3600A
  • Cause of death: ICD-8 — 3660[0-1]

2 out of 7 registries used, show all original rules.

174

4. Check minimum number of events

None

174

5. Include endpoints

None

174

6. Filter based on genotype QC (FinnGen only)

171

Control definitions (FinnGen only)

Control exclude H7_VITREOUS

Extra metadata

Level in the ICD hierarchy 4
First used in FinnGen datafreeze DF6
Parent code in ICD-10 H44
Name in latin Endophthalmitis purulenta

Case counts by codes

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FinnGen case counts by registry codes:

generic upset plot

Upset plot

Full data table

Summary Statistics

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-FinRegistry-

Key figures

All Female Male
Number of individuals
Whole population 1886 976 889
Only index persons 1367 724 643
Unadjusted period prevalence (%)
Whole population 0.03 0.03 0.02
Only index persons 0.03 0.03 0.02
Median age at first event (years)
Whole population 70.38 74.48 66.01
Only index persons 69.64 74.44 64.23

-FinnGen-

Key figures

All Female Male
Number of individuals 171 76 95
Unadjusted period prevalence (%) 0.04 0.03 0.05
Median age at first event (years) 71.32 74.16 69.05

-FinRegistry-

Age distribution of first events

-FinnGen-

Age distribution of first events

-FinRegistry-

Year distribution of first events

-FinnGen-

Year distribution of first events

-FinRegistry-

Cumulative Incidence Function

-FinnGen-

Cumulative Incidence Function

No data

Mortality – FinRegistry

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Association

Association between endpoint H7_PURENDOPHTHALMITIS and mortality.

Females

Parameter HR [95% CI] p-value
H7_PURENDOPHTHALMITIS 1.168 [0.94, 1.45] 0.163
Birth year 0.996 [0.99, 1.0] 0.398

During the follow-up period (1.1.1998 — 31.12.2019), 234 out of 595 females with H7_PURENDOPHTHALMITIS died.

Males

Parameter HR [95% CI] p-value
H7_PURENDOPHTHALMITIS 1.545 [1.18, 2.02] 0.001
Birth year 0.984 [0.97, 0.99] 0.002

During the follow-up period (1.1.1998 — 31.12.2019), 168 out of 486 males with H7_PURENDOPHTHALMITIS died.

Mortality risk

Mortality risk for people of age

years, who have H7_PURENDOPHTHALMITIS.

N-year risk Females Males
1 0.127% 0.329%
5 0.731% 1.799%
10 1.797% 4.371%
15 3.428% 8.472%
20 5.99% 13.724%

Relationships between endpoints

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Index endpoint: H7_PURENDOPHTHALMITIS – Purulent endophthalmitis

GWS hits: -

Endpoint
Case Overlap
Survival Analysis
Genetic Correlations
Genetic Signals
N (Jaccard index)
HR [CI]
Extremity
rg [CI]
Extremity
Hits
Coloc Hits
FinRegistry
FinnGen
FinRegistry
FinnGen
FinnGen
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