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Degenerative conditions of globe

DOID EFO Endpoint Browser PheWeb

H7_GLOBEDEGENERATED

Endpoint definition

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Endpoint definition steps

FinnGen

Phenotype data

473681

1. Apply sex-specific rule

None

473681

2. Check conditions

None

473681

3. Check pre-conditions, main-only, mode, registry filters

Registry filters:

  • Hospital discharge: ICD-10 — H44.5
  • Hospital discharge: ICD-9 — 3604
  • Hospital discharge: ICD-8 — 37861|37514
  • Cause of death: ICD-10 — H44.5
  • Cause of death: ICD-9 — 3604
  • Cause of death: ICD-8 — 37861|37514

2 out of 7 registries used, show all original rules.

177

4. Check minimum number of events

None

177

5. Include endpoints

None

177

6. Filter based on genotype QC (FinnGen only)

175

Control definitions (FinnGen only)

Control exclude H7_VITREOUS

Extra metadata

Level in the ICD hierarchy 4
First used in FinnGen datafreeze DF2
Parent code in ICD-10 H44
Name in latin Degeneratio bulbi oculi

Case counts by codes

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FinnGen case counts by registry codes:

generic upset plot

Upset plot

Full data table

Summary Statistics

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-FinRegistry-

Key figures

All Female Male
Number of individuals
Whole population 3241 1579 1622
Only index persons 2177 1098 1079
Unadjusted period prevalence (%)
Whole population 0.05 0.05 0.05
Only index persons 0.04 0.04 0.04
Median age at first event (years)
Whole population 71.66 76.48 66.95
Only index persons 69.72 76.15 63.17

-FinnGen-

Key figures

All Female Male
Number of individuals 175 62 113
Unadjusted period prevalence (%) 0.05 0.02 0.06
Median age at first event (years) 63.95 65.97 62.84

-FinRegistry-

Age distribution of first events

-FinnGen-

Age distribution of first events

-FinRegistry-

Year distribution of first events

-FinnGen-

Year distribution of first events

-FinRegistry-

Cumulative Incidence Function

-FinnGen-

Cumulative Incidence Function

No data

Mortality – FinRegistry

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Association

Association between endpoint H7_GLOBEDEGENERATED and mortality.

Females

Parameter HR [95% CI] p-value
H7_GLOBEDEGENERATED 1.333 [1.16, 1.54] < 0.001
Birth year 0.996 [0.99, 1.0] 0.296

During the follow-up period (1.1.1998 — 31.12.2019), 733 out of 1161 females with H7_GLOBEDEGENERATED died.

Males

Parameter HR [95% CI] p-value
H7_GLOBEDEGENERATED 1.488 [1.24, 1.78] < 0.001
Birth year 0.988 [0.98, 1.0] 0.011

During the follow-up period (1.1.1998 — 31.12.2019), 564 out of 1066 males with H7_GLOBEDEGENERATED died.

Mortality risk

Mortality risk for people of age

years, who have H7_GLOBEDEGENERATED.

N-year risk Females Males
1 0.104% 0.31%
5 0.751% 1.805%
10 1.846% 4.363%
15 3.805% 8.382%
20 6.9% 14.242%

Relationships between endpoints

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Index endpoint: H7_GLOBEDEGENERATED – Degenerative conditions of globe

GWS hits: -

Endpoint
Case Overlap
Survival Analysis
Genetic Correlations
Genetic Signals
N (Jaccard index)
HR [CI]
Extremity
rg [CI]
Extremity
Hits
Coloc Hits
FinRegistry
FinnGen
FinRegistry
FinnGen
FinnGen
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