No definition available.
Visual impairment including blindness (binocular or monocular)
DOID EFO Endpoint Browser PheWeb
H7_BLINDANDVISIMPAIRMENT
Endpoint definition
↥
Endpoint definition steps |
FinnGen |
|---|---|
Phenotype data |
473681 |
1. Apply sex-specific ruleNone |
473681 |
2. Check conditionsNone |
473681 |
3. Check pre-conditions, main-only, mode, registry filtersRegistry filters: 2 out of 7 registries used, show all original rules. |
2368 |
4. Check minimum number of eventsNone |
2368 |
5. Include endpoints |
2405 |
6. Filter based on genotype QC (FinnGen only) |
2311 |
Control definitions (FinnGen only)
Control exclude
H7_VISUALDISTBLIND
Extra metadata
Level in the ICD hierarchy
3
First used in FinnGen datafreeze
DF2
Parent code in ICD-10
H53-H54
Name in latin
Amaurosis et amblyopia
Similar endpoints
↥List of similar endpoints to
Visual impairment including blindness (binocular or monocular)
based on the number of shared cases.
Similar with more cases:
- Visual disturbances and blindness
- Diseases of the eye and adnexa
- Any event in hilmo or specialist outpatient
Similar with less cases:
Case counts by codes
↥
Summary Statistics
↥-FinRegistry-
Key figures
| All | Female | Male | |
|---|---|---|---|
| Number of individuals | |||
| Whole population | 26076 | 14702 | 11205 |
| Only index persons | 22660 | 13073 | 9587 |
| Unadjusted period prevalence (%) | |||
| Whole population | 0.37 | 0.42 | 0.31 |
| Only index persons | 0.43 | 0.48 | 0.37 |
| Median age at first event (years) | |||
| Whole population | 68.74 | 74.19 | 61.57 |
| Only index persons | 68.69 | 74.12 | 61.29 |
-FinnGen-
Key figures
| All | Female | Male | |
|---|---|---|---|
| Number of individuals | 2311 | 1315 | 996 |
| Unadjusted period prevalence (%) | 0.51 | 0.52 | 0.50 |
| Median age at first event (years) | 66.55 | 64.48 | 69.29 |
-FinRegistry-
Age distribution of first events
-FinnGen-
Age distribution of first events
-FinRegistry-
Year distribution of first events
-FinnGen-
Year distribution of first events
-FinRegistry-
Cumulative Incidence Function
-FinnGen-
Cumulative Incidence Function
Mortality – FinRegistry
↥Association
Association between endpoint H7_BLINDANDVISIMPAIRMENT and mortality.
Females
| Parameter | HR [95% CI] | p-value |
|---|---|---|
| H7_BLINDANDVISIMPAIRMENT | 1.228 [1.11, 1.36] | < 0.001 |
| Birth year | 0.993 [0.99, 1.0] | 0.091 |
During the follow-up period (1.1.1998 — 31.12.2019), 4878 out of 12825 females with H7_BLINDANDVISIMPAIRMENT died.
Males
| Parameter | HR [95% CI] | p-value |
|---|---|---|
| H7_BLINDANDVISIMPAIRMENT | 1.588 [1.4, 1.81] | < 0.001 |
| Birth year | 0.986 [0.98, 1.0] | 0.003 |
During the follow-up period (1.1.1998 — 31.12.2019), 3352 out of 9538 males with H7_BLINDANDVISIMPAIRMENT died.
Mortality risk
Mortality risk for people of age
years, who have H7_BLINDANDVISIMPAIRMENT.| N-year risk | Females | Males |
|---|---|---|
| 1 | 0.102% | 0.191% |
| 5 | 0.656% | 1.749% |
| 10 | 1.618% | 4.371% |
| 15 | 3.177% | 8.319% |
| 20 | 5.462% | 13.391% |
Relationships between endpoints
↥Index endpoint: H7_BLINDANDVISIMPAIRMENT – Visual impairment including blindness (binocular or monocular)
GWS hits: 2
Endpoint
Case Overlap
Survival Analysis
Genetic Correlations
Genetic Signals
N (Jaccard index)
HR [CI]
Extremity
rg [CI]
Extremity
Hits
Coloc Hits
FinRegistry
FinnGen
FinRegistry
FinnGen
FinnGen
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