No definition available.
Endpoint definition
↥
Endpoint definition steps |
FinnGen |
|---|---|
Phenotype data |
473681 |
1. Apply sex-specific ruleNone |
473681 |
2. Check conditionsNone |
473681 |
3. Check pre-conditions, main-only, mode, registry filtersRegistry filters: 2 out of 7 registries used, show all original rules. |
129 |
4. Check minimum number of eventsNone |
129 |
5. Include endpointsNone |
129 |
6. Filter based on genotype QC (FinnGen only) |
121 |
Control definitions (FinnGen only)
Control exclude
H7_VISUALDISTBLIND
Extra metadata
Level in the ICD hierarchy
4
First used in FinnGen datafreeze
DF2
Parent code in ICD-10
H54
Name in latin
Amblyopia non specificata unius oculi
Similar endpoints
↥List of similar endpoints to
Moderate visual impairment, monocular
based on the number of shared cases.
Similar with more cases:
- Visual impairment including blindness (binocular or monocular)
- Visual disturbances and blindness
- Diseases of the eye and adnexa
- Any event in hilmo or specialist outpatient
- Any prescribed medicine buy
Similar with less cases:
None
Case counts by codes
↥
Summary Statistics
↥-FinRegistry-
Key figures
| All | Female | Male | |
|---|---|---|---|
| Number of individuals | |||
| Whole population | 987 | 543 | 435 |
| Only index persons | 925 | 517 | 408 |
| Unadjusted period prevalence (%) | |||
| Whole population | 0.01 | 0.02 | 0.01 |
| Only index persons | 0.02 | 0.02 | 0.02 |
| Median age at first event (years) | |||
| Whole population | 56.95 | 56.64 | 57.61 |
| Only index persons | 57.76 | 57.48 | 58.11 |
-FinnGen-
Key figures
| All | Female | Male | |
|---|---|---|---|
| Number of individuals | 121 | 69 | 52 |
| Unadjusted period prevalence (%) | 0.03 | 0.03 | 0.03 |
| Median age at first event (years) | 60.74 | 56.37 | 66.55 |
-FinRegistry-
Age distribution of first events
-FinnGen-
Age distribution of first events
-FinRegistry-
Year distribution of first events
-FinnGen-
Year distribution of first events
-FinRegistry-
Cumulative Incidence Function
-FinnGen-
Cumulative Incidence Function
No data
Mortality – FinRegistry
↥Association
Association between endpoint H7_MODVISIMPMONOC and mortality.
Females
| Parameter | HR [95% CI] | p-value |
|---|---|---|
| H7_MODVISIMPMONOC | 1.208 [0.75, 1.94] | 0.434 |
| Birth year | 0.997 [0.99, 1.01] | 0.49 |
During the follow-up period (1.1.1998 — 31.12.2019), 59 out of 447 females with H7_MODVISIMPMONOC died.
Males
| Parameter | HR [95% CI] | p-value |
|---|---|---|
| H7_MODVISIMPMONOC | 1.728 [1.06, 2.82] | 0.029 |
| Birth year | 0.99 [0.98, 1.0] | 0.028 |
During the follow-up period (1.1.1998 — 31.12.2019), 70 out of 356 males with H7_MODVISIMPMONOC died.
Mortality risk
Mortality risk for people of age
years, who have H7_MODVISIMPMONOC.| N-year risk | Females | Males |
|---|---|---|
| 1 | 0.114% | 0.353% |
| 5 | 0.775% | 2.414% |
| 10 | 1.96% | 5.792% |
| 15 | 3.568% | 10.211% |
| 20 | 6.214% | 16.751% |
Relationships between endpoints
↥Index endpoint: H7_MODVISIMPMONOC – Moderate visual impairment, monocular
GWS hits: -
Endpoint
Case Overlap
Survival Analysis
Genetic Correlations
Genetic Signals
N (Jaccard index)
HR [CI]
Extremity
rg [CI]
Extremity
Hits
Coloc Hits
FinRegistry
FinnGen
FinRegistry
FinnGen
FinnGen
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