No definition available.
Endpoint definition
↥
Endpoint definition steps |
FinnGen |
|---|---|
Phenotype data |
473681 |
1. Apply sex-specific ruleNone |
473681 |
2. Check conditionsNone |
473681 |
3. Check pre-conditions, main-only, mode, registry filtersRegistry filters: 2 out of 7 registries used, show all original rules. |
146 |
4. Check minimum number of eventsNone |
146 |
5. Include endpointsNone |
146 |
6. Filter based on genotype QC (FinnGen only) |
139 |
Control definitions (FinnGen only)
Control exclude
H7_VISUALDISTBLIND
Extra metadata
Level in the ICD hierarchy
4
First used in FinnGen datafreeze
DF2
Parent code in ICD-10
H54
Name in latin
Amaurosis oculorum amborum
Similar endpoints
↥List of similar endpoints to
Blindness or visual impairment, binocular
based on the number of shared cases.
Similar with more cases:
- Visual impairment including blindness (binocular or monocular)
- Visual disturbances and blindness
- Diseases of the eye and adnexa
- Any operation in hilmo
- Any event in hilmo or specialist outpatient
Similar with less cases:
None
Case counts by codes
↥
Summary Statistics
↥-FinRegistry-
Key figures
| All | Female | Male | |
|---|---|---|---|
| Number of individuals | |||
| Whole population | 2294 | 1145 | 1123 |
| Only index persons | 1910 | 996 | 914 |
| Unadjusted period prevalence (%) | |||
| Whole population | 0.03 | 0.03 | 0.03 |
| Only index persons | 0.04 | 0.04 | 0.03 |
| Median age at first event (years) | |||
| Whole population | 62.61 | 64.75 | 60.11 |
| Only index persons | 61.83 | 64.18 | 59.26 |
-FinnGen-
Key figures
| All | Female | Male | |
|---|---|---|---|
| Number of individuals | 139 | 72 | 67 |
| Unadjusted period prevalence (%) | 0.03 | 0.03 | 0.03 |
| Median age at first event (years) | 56.21 | 52.53 | 60.15 |
-FinRegistry-
Age distribution of first events
-FinnGen-
Age distribution of first events
-FinRegistry-
Year distribution of first events
-FinnGen-
Year distribution of first events
-FinRegistry-
Cumulative Incidence Function
-FinnGen-
Cumulative Incidence Function
No data
Mortality – FinRegistry
↥Association
Association between endpoint H7_VISIMPBILATERAL and mortality.
Females
| Parameter | HR [95% CI] | p-value |
|---|---|---|
| H7_VISIMPBILATERAL | 2.117 [1.63, 2.75] | < 0.001 |
| Birth year | 0.993 [0.98, 1.0] | 0.088 |
During the follow-up period (1.1.1998 — 31.12.2019), 416 out of 1022 females with H7_VISIMPBILATERAL died.
Males
| Parameter | HR [95% CI] | p-value |
|---|---|---|
| H7_VISIMPBILATERAL | 2.19 [1.67, 2.87] | < 0.001 |
| Birth year | 0.988 [0.98, 1.0] | 0.014 |
During the follow-up period (1.1.1998 — 31.12.2019), 413 out of 986 males with H7_VISIMPBILATERAL died.
Mortality risk
Mortality risk for people of age
years, who have H7_VISIMPBILATERAL.| N-year risk | Females | Males |
|---|---|---|
| 1 | 0.167% | 0.477% |
| 5 | 0.988% | 2.345% |
| 10 | 2.677% | 6.198% |
| 15 | 5.119% | 11.656% |
| 20 | 9.06% | 20.056% |
Relationships between endpoints
↥Index endpoint: H7_VISIMPBILATERAL – Blindness or visual impairment, binocular
GWS hits: -
Endpoint
Case Overlap
Survival Analysis
Genetic Correlations
Genetic Signals
N (Jaccard index)
HR [CI]
Extremity
rg [CI]
Extremity
Hits
Coloc Hits
FinRegistry
FinnGen
FinRegistry
FinnGen
FinnGen
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