No definition available.
Endpoint definition
↥
Endpoint definition steps |
FinnGen |
|---|---|
Phenotype data |
473681 |
1. Apply sex-specific ruleNone |
473681 |
2. Check conditionsNone |
473681 |
3. Check pre-conditions, main-only, mode, registry filtersRegistry filters: 2 out of 7 registries used, show all original rules. |
1035 |
4. Check minimum number of eventsNone |
1035 |
5. Include endpointsNone |
1035 |
6. Filter based on genotype QC (FinnGen only) |
998 |
Control definitions (FinnGen only)
Control exclude
H7_VISUALDISTBLIND
Extra metadata
Level in the ICD hierarchy
4
First used in FinnGen datafreeze
DF2
Parent code in ICD-10
H54
Name in latin
Amblyopia oculorum amborum
Similar endpoints
↥List of similar endpoints to
Moderate visual impairment, binocular
based on the number of shared cases.
Similar with more cases:
- Visual impairment including blindness (binocular or monocular)
- Visual disturbances and blindness
- Diseases of the eye and adnexa
- Any event in hilmo or specialist outpatient
- Any prescribed medicine buy
Similar with less cases:
None
Case counts by codes
↥
Summary Statistics
↥-FinRegistry-
Key figures
| All | Female | Male | |
|---|---|---|---|
| Number of individuals | |||
| Whole population | 10909 | 6761 | 4095 |
| Only index persons | 9667 | 6101 | 3566 |
| Unadjusted period prevalence (%) | |||
| Whole population | 0.16 | 0.19 | 0.11 |
| Only index persons | 0.19 | 0.22 | 0.14 |
| Median age at first event (years) | |||
| Whole population | 77.24 | 80.52 | 71.83 |
| Only index persons | 77.28 | 80.62 | 71.56 |
-FinnGen-
Key figures
| All | Female | Male | |
|---|---|---|---|
| Number of individuals | 998 | 583 | 415 |
| Unadjusted period prevalence (%) | 0.22 | 0.23 | 0.21 |
| Median age at first event (years) | 73.84 | 73.57 | 74.23 |
-FinRegistry-
Age distribution of first events
-FinnGen-
Age distribution of first events
-FinRegistry-
Year distribution of first events
-FinnGen-
Year distribution of first events
-FinRegistry-
Cumulative Incidence Function
-FinnGen-
Cumulative Incidence Function
Mortality – FinRegistry
↥Association
Association between endpoint H7_MODVISIMPBINOC and mortality.
Females
| Parameter | HR [95% CI] | p-value |
|---|---|---|
| H7_MODVISIMPBINOC | 1.164 [1.04, 1.31] | 0.01 |
| Birth year | 0.989 [0.98, 1.0] | 0.014 |
During the follow-up period (1.1.1998 — 31.12.2019), 3101 out of 6258 females with H7_MODVISIMPBINOC died.
Males
| Parameter | HR [95% CI] | p-value |
|---|---|---|
| H7_MODVISIMPBINOC | 1.401 [1.2, 1.63] | < 0.001 |
| Birth year | 0.986 [0.98, 1.0] | 0.003 |
During the follow-up period (1.1.1998 — 31.12.2019), 1750 out of 3780 males with H7_MODVISIMPBINOC died.
Mortality risk
Mortality risk for people of age
years, who have H7_MODVISIMPBINOC.| N-year risk | Females | Males |
|---|---|---|
| 1 | 0.105% | 0.199% |
| 5 | 0.573% | 1.616% |
| 10 | 1.448% | 4.074% |
| 15 | 2.741% | 7.38% |
| 20 | 4.724% | 12.271% |
Relationships between endpoints
↥Index endpoint: H7_MODVISIMPBINOC – Moderate visual impairment, binocular
GWS hits: 3
Endpoint
Case Overlap
Survival Analysis
Genetic Correlations
Genetic Signals
N (Jaccard index)
HR [CI]
Extremity
rg [CI]
Extremity
Hits
Coloc Hits
FinRegistry
FinnGen
FinRegistry
FinnGen
FinnGen
Loading data