No definition available.
Endpoint definition
↥
Endpoint definition steps |
FinnGen |
|---|---|
Phenotype data |
473681 |
1. Apply sex-specific ruleNone |
473681 |
2. Check conditionsNone |
473681 |
3. Check pre-conditions, main-only, mode, registry filtersRegistry filters: 2 out of 7 registries used, show all original rules. |
283 |
4. Check minimum number of eventsNone |
283 |
5. Include endpointsNone |
283 |
6. Filter based on genotype QC (FinnGen only) |
276 |
Control definitions (FinnGen only)
Control exclude
H7_VISUALDISTBLIND
Extra metadata
Level in the ICD hierarchy
4
First used in FinnGen datafreeze
DF2
Parent code in ICD-10
H54
Name in latin
Amaurosis unius oculi
Similar endpoints
↥List of similar endpoints to
Blindness, monocular
based on the number of shared cases.
Similar with more cases:
- Visual impairment including blindness (binocular or monocular)
- Visual disturbances and blindness
- Diseases of the eye and adnexa
- Any event in hilmo or specialist outpatient
- Any prescribed medicine buy
Similar with less cases:
None
Case counts by codes
↥
Summary Statistics
↥-FinRegistry-
Key figures
| All | Female | Male | |
|---|---|---|---|
| Number of individuals | |||
| Whole population | 2797 | 1353 | 1421 |
| Only index persons | 2501 | 1233 | 1268 |
| Unadjusted period prevalence (%) | |||
| Whole population | 0.04 | 0.04 | 0.04 |
| Only index persons | 0.05 | 0.05 | 0.05 |
| Median age at first event (years) | |||
| Whole population | 68.28 | 72.20 | 64.44 |
| Only index persons | 67.17 | 71.56 | 62.91 |
-FinnGen-
Key figures
| All | Female | Male | |
|---|---|---|---|
| Number of individuals | 276 | 143 | 133 |
| Unadjusted period prevalence (%) | 0.06 | 0.06 | 0.07 |
| Median age at first event (years) | 64.09 | 62.78 | 65.50 |
-FinRegistry-
Age distribution of first events
-FinnGen-
Age distribution of first events
-FinRegistry-
Year distribution of first events
-FinnGen-
Year distribution of first events
-FinRegistry-
Cumulative Incidence Function
-FinnGen-
Cumulative Incidence Function
No data
Mortality – FinRegistry
↥Association
Association between endpoint H7_BLINDMONOCULAR and mortality.
Females
| Parameter | HR [95% CI] | p-value |
|---|---|---|
| H7_BLINDMONOCULAR | 1.341 [1.11, 1.62] | 0.003 |
| Birth year | 0.995 [0.99, 1.0] | 0.25 |
During the follow-up period (1.1.1998 — 31.12.2019), 434 out of 1186 females with H7_BLINDMONOCULAR died.
Males
| Parameter | HR [95% CI] | p-value |
|---|---|---|
| H7_BLINDMONOCULAR | 1.671 [1.36, 2.06] | < 0.001 |
| Birth year | 0.987 [0.98, 1.0] | 0.007 |
During the follow-up period (1.1.1998 — 31.12.2019), 458 out of 1223 males with H7_BLINDMONOCULAR died.
Mortality risk
Mortality risk for people of age
years, who have H7_BLINDMONOCULAR.| N-year risk | Females | Males |
|---|---|---|
| 1 | 0.173% | 0.358% |
| 5 | 0.869% | 2.093% |
| 10 | 1.878% | 4.866% |
| 15 | 3.93% | 9.27% |
| 20 | 6.913% | 16.066% |
Relationships between endpoints
↥Index endpoint: H7_BLINDMONOCULAR – Blindness, monocular
GWS hits: -
Endpoint
Case Overlap
Survival Analysis
Genetic Correlations
Genetic Signals
N (Jaccard index)
HR [CI]
Extremity
rg [CI]
Extremity
Hits
Coloc Hits
FinRegistry
FinnGen
FinRegistry
FinnGen
FinnGen
Loading data