No definition available.
Endpoint definition
↥
Endpoint definition steps |
FinnGen |
|---|---|
Phenotype data |
473681 |
1. Apply sex-specific ruleNone |
473681 |
2. Check conditionsNone |
473681 |
3. Check pre-conditions, main-only, mode, registry filtersRegistry filters: 2 out of 7 registries used, show all original rules. |
149 |
4. Check minimum number of eventsNone |
149 |
5. Include endpointsNone |
149 |
6. Filter based on genotype QC (FinnGen only) |
146 |
Control definitions (FinnGen only)
Control exclude
H7_VISUALDISTBLIND
Extra metadata
Level in the ICD hierarchy
4
First used in FinnGen datafreeze
DF2
Parent code in ICD-10
H54
Name in latin
Amaurosis unius oculi, amblyopia alterius oculi
Similar endpoints
↥List of similar endpoints to
Severe visual impairment, binocular
based on the number of shared cases.
Similar with more cases:
- Visual impairment including blindness (binocular or monocular)
- Visual disturbances and blindness
- Diseases of the eye and adnexa
- Any event in hilmo or specialist outpatient
- Any prescribed medicine buy
Similar with less cases:
None
Case counts by codes
↥
Summary Statistics
↥-FinRegistry-
Key figures
| All | Female | Male | |
|---|---|---|---|
| Number of individuals | |||
| Whole population | 1513 | 827 | 679 |
| Only index persons | 1404 | 779 | 625 |
| Unadjusted period prevalence (%) | |||
| Whole population | 0.02 | 0.02 | 0.02 |
| Only index persons | 0.03 | 0.03 | 0.02 |
| Median age at first event (years) | |||
| Whole population | 74.74 | 78.44 | 70.27 |
| Only index persons | 74.85 | 78.51 | 70.27 |
-FinnGen-
Key figures
| All | Female | Male | |
|---|---|---|---|
| Number of individuals | 146 | 76 | 70 |
| Unadjusted period prevalence (%) | 0.03 | 0.03 | 0.04 |
| Median age at first event (years) | 70.52 | 69.92 | 71.17 |
-FinRegistry-
Age distribution of first events
-FinnGen-
Age distribution of first events
-FinRegistry-
Year distribution of first events
-FinnGen-
Year distribution of first events
-FinRegistry-
Cumulative Incidence Function
-FinnGen-
Cumulative Incidence Function
No data
Mortality – FinRegistry
↥Association
Association between endpoint H7_SEVVISIMPBINOC and mortality.
Females
| Parameter | HR [95% CI] | p-value |
|---|---|---|
| H7_SEVVISIMPBINOC | 1.435 [1.09, 1.88] | 0.009 |
| Birth year | 0.988 [0.98, 1.0] | 0.008 |
During the follow-up period (1.1.1998 — 31.12.2019), 296 out of 721 females with H7_SEVVISIMPBINOC died.
Males
| Parameter | HR [95% CI] | p-value |
|---|---|---|
| H7_SEVVISIMPBINOC | 1.576 [1.15, 2.15] | 0.004 |
| Birth year | 0.989 [0.98, 1.0] | 0.019 |
During the follow-up period (1.1.1998 — 31.12.2019), 257 out of 605 males with H7_SEVVISIMPBINOC died.
Mortality risk
Mortality risk for people of age
years, who have H7_SEVVISIMPBINOC.| N-year risk | Females | Males |
|---|---|---|
| 1 | 0.115% | 0.294% |
| 5 | 0.592% | 1.968% |
| 10 | 1.64% | 4.809% |
| 15 | 3.245% | 9.312% |
| 20 | 5.846% | 15.604% |
Relationships between endpoints
↥Index endpoint: H7_SEVVISIMPBINOC – Severe visual impairment, binocular
GWS hits: 1
Endpoint
Case Overlap
Survival Analysis
Genetic Correlations
Genetic Signals
N (Jaccard index)
HR [CI]
Extremity
rg [CI]
Extremity
Hits
Coloc Hits
FinRegistry
FinnGen
FinRegistry
FinnGen
FinnGen
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