Benign neoplasm of other and ill-defined parts of digestive system

CD2_BENIGN_OTHERDIGESTIVE

colonic neoplasm: A benign or malignant neoplasm that affects the colon. Representative examples of benign neoplasms include lipoma and leiomyoma. Representative examples of malignant neoplasms include carcinoma, lymphoma, and sarcoma. Colonic adenomas always exhibit epithelial dysplasia and are considered premalignant neoplasms.

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Endpoint definition

Endpoint definition steps

FinnGen

Phenotype data

473681

1. Apply sex-specific rule

None

473681

2. Check conditions

None

473681

3. Check pre-conditions, main-only, mode, registry filters

Registry filters:

  • Hospital discharge: ICD-10 D13
  • Cause of death: ICD-10 D13

2 out of 7 registries used, show all original rules.

6216

4. Check minimum number of events

None

6216

5. Include endpoints

6419

6. Filter based on genotype QC (FinnGen only)

6205

Control definitions (FinnGen only)

Controls for this endpoint are individuals that are not cases.

Extra metadata

Level in the ICD hierarchy 2
First used in FinnGen datafreeze DF2
Parent code in ICD-10 D10-D36
Name in latin Neoplasmata benigna aliarum sive male specificatarum partium organorum digestoriorum

Similar endpoints

List of similar endpoints to Benign neoplasm of other and ill-defined parts of digestive system based on the number of shared cases.

Venn diagram with an highlighted set fully inside another set Similar with more cases:

Venn diagram with a set fully inside an highlighted set Similar with less cases:

Case counts by codes

FinnGen case counts by registry codes:

generic upset plot

Upset plot

Full data table

Summary Statistics

-FinRegistry-

Key figures

All Female Male
Number of individuals
Whole population 38929 23451 15222
Only index persons 34801 21473 13328
Unadjusted period prevalence (%)
Whole population 0.57 0.67 0.43
Only index persons 0.68 0.79 0.51
Median age at first event (years)
Whole population 64.36 63.60 65.50
Only index persons 63.69 62.85 65.06

-FinnGen-

Key figures

All Female Male
Number of individuals 6205 3835 2370
Unadjusted period prevalence (%) 1.39 1.51 1.19
Median age at first event (years) 63.19 60.97 66.77

-FinRegistry-

Age distribution of first events

-FinnGen-

Age distribution of first events

-FinRegistry-

Year distribution of first events

-FinnGen-

Year distribution of first events

-FinRegistry-

Cumulative Incidence Function

-FinnGen-

Cumulative Incidence Function

Mortality – FinRegistry

Association

Association between endpoint CD2_BENIGN_OTHERDIGESTIVE and mortality.

Females

Parameter HR [95% CI] p-value
CD2_BENIGN_OTHERDIGESTIVE 1.533 [1.4, 1.68] < 0.001
Birth year 0.993 [0.98, 1.0] 0.079

During the follow-up period (1.1.1998 — 31.12.2019), 3953 out of 18442 females with CD2_BENIGN_OTHERDIGESTIVE died.

Males

Parameter HR [95% CI] p-value
CD2_BENIGN_OTHERDIGESTIVE 1.696 [1.53, 1.88] < 0.001
Birth year 0.984 [0.98, 0.99] < 0.001

During the follow-up period (1.1.1998 — 31.12.2019), 3753 out of 11744 males with CD2_BENIGN_OTHERDIGESTIVE died.

Mortality risk

Mortality risk for people of age

years, who have CD2_BENIGN_OTHERDIGESTIVE.

N-year risk Females Males
1 0.146% 0.349%
5 0.926% 1.828%
10 2.151% 4.674%
15 4.085% 8.492%
20 6.931% 14.357%

Relationships between endpoints

Index endpoint: CD2_BENIGN_OTHERDIGESTIVE – Benign neoplasm of other and ill-defined parts of digestive system

GWS hits: -

Endpoint
Case Overlap
Survival Analysis
Genetic Correlations
Genetic Signals
N (Jaccard index)
HR [CI]
Extremity
rg [CI]
Extremity
Hits
Coloc Hits
FinRegistry
FinnGen
FinRegistry
FinnGen
FinnGen
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