Benign neoplasm: Ill-defined sites within the digestive system

CD2_BENIGN_DIGESTIVE_NOS

Endpoint definition

Endpoint definition steps

FinnGen

Phenotype data

473681

1. Apply sex-specific rule

None

473681

2. Check conditions

None

473681

3. Check pre-conditions, main-only, mode, registry filters

Registry filters:

  • Hospital discharge: ICD-10 D13.9&
  • Hospital discharge: ICD-9 2119
  • Hospital discharge: ICD-8 21199
  • Cause of death: ICD-10 D13.9&
  • Cause of death: ICD-9 2119
  • Cause of death: ICD-8 21199

2 out of 7 registries used, show all original rules.

186

4. Check minimum number of events

None

186

5. Include endpoints

None

186

6. Filter based on genotype QC (FinnGen only)

182

Control definitions (FinnGen only)

Controls for this endpoint are individuals that are not cases.

Extra metadata

Level in the ICD hierarchy 3
First used in FinnGen datafreeze DF2
Parent code in ICD-10 D13
Name in latin Neoplasma benignum systematis digestorii loco male specificato

Case counts by codes

FinnGen case counts by registry codes:

generic upset plot

Upset plot

Full data table

Summary Statistics

-FinRegistry-

Key figures

All Female Male
Number of individuals
Whole population 1435 836 586
Only index persons 1139 692 447
Unadjusted period prevalence (%)
Whole population 0.02 0.02 0.02
Only index persons 0.02 0.03 0.02
Median age at first event (years)
Whole population 61.79 60.50 63.56
Only index persons 60.47 58.95 62.82

-FinnGen-

Key figures

All Female Male
Number of individuals 182 118 64
Unadjusted period prevalence (%) 0.04 0.05 0.03
Median age at first event (years) 61.55 59.79 64.79

-FinRegistry-

Age distribution of first events

-FinnGen-

Age distribution of first events

-FinRegistry-

Year distribution of first events

-FinnGen-

Year distribution of first events

-FinRegistry-

Cumulative Incidence Function

-FinnGen-

Cumulative Incidence Function

No data

Mortality – FinRegistry

Association

Association between endpoint CD2_BENIGN_DIGESTIVE_NOS and mortality.

Females

Parameter HR [95% CI] p-value
CD2_BENIGN_DIGESTIVE_NOS 1.908 [1.49, 2.44] < 0.001
Birth year 0.994 [0.99, 1.0] 0.146

During the follow-up period (1.1.1998 — 31.12.2019), 158 out of 500 females with CD2_BENIGN_DIGESTIVE_NOS died.

Males

Parameter HR [95% CI] p-value
CD2_BENIGN_DIGESTIVE_NOS 1.995 [1.48, 2.68] < 0.001
Birth year 0.983 [0.97, 0.99] 0.001

During the follow-up period (1.1.1998 — 31.12.2019), 139 out of 332 males with CD2_BENIGN_DIGESTIVE_NOS died.

Mortality risk

Mortality risk for people of age

years, who have CD2_BENIGN_DIGESTIVE_NOS.

N-year risk Females Males
1 0.224% 0.335%
5 1.08% 2.077%
10 2.401% 5.039%
15 4.887% 9.237%
20 8.89% 15.301%

Relationships between endpoints

Index endpoint: CD2_BENIGN_DIGESTIVE_NOS – Benign neoplasm: Ill-defined sites within the digestive system

GWS hits: 1

Endpoint
Case Overlap
Survival Analysis
Genetic Correlations
Genetic Signals
N (Jaccard index)
HR [CI]
Extremity
rg [CI]
Extremity
Hits
Coloc Hits
FinRegistry
FinnGen
FinRegistry
FinnGen
FinnGen
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