Benign neoplasm of mouth and pharynx

CD2_BENIGN_MOUTH_PHARYNX

Endpoint definition

Endpoint definition steps

FinnGen

Phenotype data

473681

1. Apply sex-specific rule

None

473681

2. Check conditions

None

473681

3. Check pre-conditions, main-only, mode, registry filters

Registry filters:

  • Hospital discharge: ICD-10 D10
  • Cause of death: ICD-10 D10

2 out of 7 registries used, show all original rules.

3685

4. Check minimum number of events

None

3685

5. Include endpoints

3966

6. Filter based on genotype QC (FinnGen only)

3821

Control definitions (FinnGen only)

Controls for this endpoint are individuals that are not cases.

Extra metadata

Level in the ICD hierarchy 2
First used in FinnGen datafreeze DF2
Parent code in ICD-10 D10-D36
Name in latin Neoplasma benignum oris sive pharyngis

Case counts by codes

FinnGen case counts by registry codes:

generic upset plot

Upset plot

Full data table

Summary Statistics

-FinRegistry-

Key figures

All Female Male
Number of individuals
Whole population 30467 16198 14066
Only index persons 27451 14935 12516
Unadjusted period prevalence (%)
Whole population 0.43 0.46 0.39
Only index persons 0.52 0.55 0.48
Median age at first event (years)
Whole population 55.34 55.81 54.77
Only index persons 54.50 55.16 53.72

-FinnGen-

Key figures

All Female Male
Number of individuals 3821 2087 1734
Unadjusted period prevalence (%) 0.84 0.82 0.87
Median age at first event (years) 57.22 55.43 59.37

-FinRegistry-

Age distribution of first events

-FinnGen-

Age distribution of first events

-FinRegistry-

Year distribution of first events

-FinnGen-

Year distribution of first events

-FinRegistry-

Cumulative Incidence Function

-FinnGen-

Cumulative Incidence Function

Mortality – FinRegistry

Association

Association between endpoint CD2_BENIGN_MOUTH_PHARYNX and mortality.

Females

Parameter HR [95% CI] p-value
CD2_BENIGN_MOUTH_PHARYNX 1.122 [1.02, 1.23] 0.016
Birth year 0.996 [0.99, 1.0] 0.365

During the follow-up period (1.1.1998 — 31.12.2019), 2155 out of 12804 females with CD2_BENIGN_MOUTH_PHARYNX died.

Males

Parameter HR [95% CI] p-value
CD2_BENIGN_MOUTH_PHARYNX 1.3 [1.18, 1.43] < 0.001
Birth year 0.994 [0.98, 1.0] 0.204

During the follow-up period (1.1.1998 — 31.12.2019), 2523 out of 10970 males with CD2_BENIGN_MOUTH_PHARYNX died.

Mortality risk

Mortality risk for people of age

years, who have CD2_BENIGN_MOUTH_PHARYNX.

N-year risk Females Males
1 0.094% 0.33%
5 0.624% 1.878%
10 1.662% 4.503%
15 3.1% 8.47%
20 5.655% 14.488%

Relationships between endpoints

Index endpoint: CD2_BENIGN_MOUTH_PHARYNX – Benign neoplasm of mouth and pharynx

GWS hits: -

Endpoint
Case Overlap
Survival Analysis
Genetic Correlations
Genetic Signals
N (Jaccard index)
HR [CI]
Extremity
rg [CI]
Extremity
Hits
Coloc Hits
FinRegistry
FinnGen
FinRegistry
FinnGen
FinnGen
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