Benign neoplasm: Other and unspecified parts of mouth

CD2_BENIGN_MOUTH_NOS

ossifying fibroma: A bone benign neoplasm that is located_in the mouth and results_in an overgrowth of gingival tissue due to irritation or trauma.

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Endpoint definition

Endpoint definition steps

FinnGen

Phenotype data

473681

1. Apply sex-specific rule

None

473681

2. Check conditions

None

473681

3. Check pre-conditions, main-only, mode, registry filters

Registry filters:

  • Hospital discharge: ICD-10 D10.3
  • Hospital discharge: ICD-9 2104
  • Hospital discharge: ICD-8 2104
  • Cause of death: ICD-10 D10.3
  • Cause of death: ICD-9 2104
  • Cause of death: ICD-8 2104

2 out of 7 registries used, show all original rules.

1123

4. Check minimum number of events

None

1123

5. Include endpoints

None

1123

6. Filter based on genotype QC (FinnGen only)

1089

Control definitions (FinnGen only)

Controls for this endpoint are individuals that are not cases.

Extra metadata

Level in the ICD hierarchy 3
First used in FinnGen datafreeze DF2
Parent code in ICD-10 D10
Name in latin Neoplasma benignum partium oris aliarum sive non specificatarum

Case counts by codes

FinnGen case counts by registry codes:

generic upset plot

Upset plot

Full data table

Summary Statistics

-FinRegistry-

Key figures

All Female Male
Number of individuals
Whole population 8787 4911 3828
Only index persons 8081 4588 3493
Unadjusted period prevalence (%)
Whole population 0.13 0.14 0.11
Only index persons 0.15 0.17 0.13
Median age at first event (years)
Whole population 54.40 55.07 53.48
Only index persons 53.69 54.56 52.55

-FinnGen-

Key figures

All Female Male
Number of individuals 1089 607 482
Unadjusted period prevalence (%) 0.24 0.24 0.24
Median age at first event (years) 56.89 56.06 57.94

-FinRegistry-

Age distribution of first events

-FinnGen-

Age distribution of first events

-FinRegistry-

Year distribution of first events

-FinnGen-

Year distribution of first events

-FinRegistry-

Cumulative Incidence Function

-FinnGen-

Cumulative Incidence Function

Mortality – FinRegistry

Association

Association between endpoint CD2_BENIGN_MOUTH_NOS and mortality.

Females

Parameter HR [95% CI] p-value
CD2_BENIGN_MOUTH_NOS 1.144 [1.02, 1.29] 0.025
Birth year 0.995 [0.99, 1.0] 0.208

During the follow-up period (1.1.1998 — 31.12.2019), 610 out of 4031 females with CD2_BENIGN_MOUTH_NOS died.

Males

Parameter HR [95% CI] p-value
CD2_BENIGN_MOUTH_NOS 1.19 [1.05, 1.35] 0.006
Birth year 0.992 [0.98, 1.0] 0.113

During the follow-up period (1.1.1998 — 31.12.2019), 636 out of 3156 males with CD2_BENIGN_MOUTH_NOS died.

Mortality risk

Mortality risk for people of age

years, who have CD2_BENIGN_MOUTH_NOS.

N-year risk Females Males
1 0.054% 0.272%
5 0.611% 1.598%
10 1.591% 3.938%
15 3.274% 7.422%
20 5.738% 12.371%

Relationships between endpoints

Index endpoint: CD2_BENIGN_MOUTH_NOS – Benign neoplasm: Other and unspecified parts of mouth

GWS hits: -

Endpoint
Case Overlap
Survival Analysis
Genetic Correlations
Genetic Signals
N (Jaccard index)
HR [CI]
Extremity
rg [CI]
Extremity
Hits
Coloc Hits
FinRegistry
FinnGen
FinRegistry
FinnGen
FinnGen
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