Benign neoplasm: Other parts of oropharynx

CD2_BENIGN_OROPHA_OTHER

Endpoint definition

Endpoint definition steps

FinnGen

Phenotype data

473681

1. Apply sex-specific rule

None

473681

2. Check conditions

None

473681

3. Check pre-conditions, main-only, mode, registry filters

Registry filters:

  • Hospital discharge: ICD-10 D10.5&
  • Hospital discharge: ICD-9 2106
  • Hospital discharge: ICD-8 2106
  • Cause of death: ICD-10 D10.5&
  • Cause of death: ICD-9 2106
  • Cause of death: ICD-8 2106

2 out of 7 registries used, show all original rules.

290

4. Check minimum number of events

None

290

5. Include endpoints

None

290

6. Filter based on genotype QC (FinnGen only)

279

Control definitions (FinnGen only)

Controls for this endpoint are individuals that are not cases.

Extra metadata

Level in the ICD hierarchy 3
First used in FinnGen datafreeze DF2
Parent code in ICD-10 D10
Name in latin Neoplasma benignum oropharyngis

Case counts by codes

FinnGen case counts by registry codes:

generic upset plot

Upset plot

Full data table

Summary Statistics

-FinRegistry-

Key figures

All Female Male
Number of individuals
Whole population 2025 1071 939
Only index persons 1865 1002 863
Unadjusted period prevalence (%)
Whole population 0.03 0.03 0.03
Only index persons 0.04 0.04 0.03
Median age at first event (years)
Whole population 51.53 52.28 50.52
Only index persons 50.66 51.48 49.72

-FinnGen-

Key figures

All Female Male
Number of individuals 279 163 116
Unadjusted period prevalence (%) 0.06 0.06 0.06
Median age at first event (years) 54.23 52.65 56.46

-FinRegistry-

Age distribution of first events

-FinnGen-

Age distribution of first events

-FinRegistry-

Year distribution of first events

-FinnGen-

Year distribution of first events

-FinRegistry-

Cumulative Incidence Function

-FinnGen-

Cumulative Incidence Function

No data

Mortality – FinRegistry

Association

Association between endpoint CD2_BENIGN_OROPHA_OTHER and mortality.

Females

Parameter HR [95% CI] p-value
CD2_BENIGN_OROPHA_OTHER 1.256 [0.99, 1.6] 0.063
Birth year 0.996 [0.99, 1.01] 0.452

During the follow-up period (1.1.1998 — 31.12.2019), 117 out of 834 females with CD2_BENIGN_OROPHA_OTHER died.

Males

Parameter HR [95% CI] p-value
CD2_BENIGN_OROPHA_OTHER 1.677 [1.28, 2.2] < 0.001
Birth year 0.986 [0.98, 1.0] 0.003

During the follow-up period (1.1.1998 — 31.12.2019), 137 out of 733 males with CD2_BENIGN_OROPHA_OTHER died.

Mortality risk

Mortality risk for people of age

years, who have CD2_BENIGN_OROPHA_OTHER.

N-year risk Females Males
1 0.14% 0.328%
5 0.857% 1.893%
10 2.044% 4.924%
15 3.593% 9.149%
20 6.503% 14.734%

Relationships between endpoints

Index endpoint: CD2_BENIGN_OROPHA_OTHER – Benign neoplasm: Other parts of oropharynx

GWS hits: -

Endpoint
Case Overlap
Survival Analysis
Genetic Correlations
Genetic Signals
N (Jaccard index)
HR [CI]
Extremity
rg [CI]
Extremity
Hits
Coloc Hits
FinRegistry
FinnGen
FinRegistry
FinnGen
FinnGen
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