brain neoplasm: A neoplasm (disease) that involves the brain.
Benign neoplasm of brain and other parts of central nervous system
DOID EFO Endpoint Browser PheWeb
CD2_BENIGN_BRAIN_CNS
Endpoint definition
↥
Endpoint definition steps |
FinnGen |
|---|---|
Phenotype data |
473681 |
1. Apply sex-specific ruleNone |
473681 |
2. Check conditionsNone |
473681 |
3. Check pre-conditions, main-only, mode, registry filtersRegistry filters: 2 out of 7 registries used, show all original rules. |
2030 |
4. Check minimum number of eventsNone |
2030 |
5. Include endpoints |
2228 |
6. Filter based on genotype QC (FinnGen only) |
2147 |
Control definitions (FinnGen only)
Controls for this endpoint are individuals that are not cases.
Extra metadata
Level in the ICD hierarchy
2
First used in FinnGen datafreeze
DF2
Parent code in ICD-10
D10-D36
Name in latin
Neoplasmata benigna systematis nervosi centralis et nervorum cranialium
Similar endpoints
↥List of similar endpoints to
Benign neoplasm of brain and other parts of central nervous system
based on the number of shared cases.
Similar with more cases:
- Benign neoplasm of brain and other parts of central nervous system
- Benign neoplasms
- Benign neoplasms
- Neoplasms
- Any event in hilmo or specialist outpatient
Similar with less cases:
Case counts by codes
↥
Summary Statistics
↥-FinRegistry-
Key figures
| All | Female | Male | |
|---|---|---|---|
| Number of individuals | |||
| Whole population | 16990 | 9327 | 7538 |
| Only index persons | 14502 | 8017 | 6485 |
| Unadjusted period prevalence (%) | |||
| Whole population | 0.24 | 0.27 | 0.21 |
| Only index persons | 0.27 | 0.29 | 0.25 |
| Median age at first event (years) | |||
| Whole population | 52.95 | 54.19 | 51.37 |
| Only index persons | 51.94 | 53.03 | 50.59 |
-FinnGen-
Key figures
| All | Female | Male | |
|---|---|---|---|
| Number of individuals | 2147 | 1220 | 927 |
| Unadjusted period prevalence (%) | 0.47 | 0.48 | 0.47 |
| Median age at first event (years) | 53.53 | 52.26 | 55.19 |
-FinRegistry-
Age distribution of first events
-FinnGen-
Age distribution of first events
-FinRegistry-
Year distribution of first events
-FinnGen-
Year distribution of first events
-FinRegistry-
Cumulative Incidence Function
-FinnGen-
Cumulative Incidence Function
Mortality – FinRegistry
↥Association
Association between endpoint CD2_BENIGN_BRAIN_CNS and mortality.
Females
| Parameter | HR [95% CI] | p-value |
|---|---|---|
| CD2_BENIGN_BRAIN_CNS | 1.426 [1.28, 1.59] | < 0.001 |
| Birth year | 0.992 [0.98, 1.0] | 0.067 |
During the follow-up period (1.1.1998 — 31.12.2019), 1002 out of 6194 females with CD2_BENIGN_BRAIN_CNS died.
Males
| Parameter | HR [95% CI] | p-value |
|---|---|---|
| CD2_BENIGN_BRAIN_CNS | 1.535 [1.36, 1.73] | < 0.001 |
| Birth year | 0.988 [0.98, 1.0] | 0.01 |
During the follow-up period (1.1.1998 — 31.12.2019), 982 out of 5169 males with CD2_BENIGN_BRAIN_CNS died.
Mortality risk
Mortality risk for people of age
years, who have CD2_BENIGN_BRAIN_CNS.| N-year risk | Females | Males |
|---|---|---|
| 1 | 0.151% | 0.282% |
| 5 | 0.758% | 1.884% |
| 10 | 1.852% | 4.34% |
| 15 | 3.776% | 7.947% |
| 20 | 6.515% | 13.483% |
Relationships between endpoints
↥Index endpoint: CD2_BENIGN_BRAIN_CNS – Benign neoplasm of brain and other parts of central nervous system
GWS hits: 1
Endpoint
Case Overlap
Survival Analysis
Genetic Correlations
Genetic Signals
N (Jaccard index)
HR [CI]
Extremity
rg [CI]
Extremity
Hits
Coloc Hits
FinRegistry
FinnGen
FinRegistry
FinnGen
FinnGen
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