Benign neoplasm: Brain, infratentorial

CD2_BENIGN_BRAIN_INFRATENT

Endpoint definition

Endpoint definition steps

FinnGen

Phenotype data

473681

1. Apply sex-specific rule

None

473681

2. Check conditions

None

473681

3. Check pre-conditions, main-only, mode, registry filters

Registry filters:

  • Hospital discharge: ICD-10 D33.1
  • Cause of death: ICD-10 D33.1

2 out of 7 registries used, show all original rules.

185

4. Check minimum number of events

None

185

5. Include endpoints

None

185

6. Filter based on genotype QC (FinnGen only)

178

Control definitions (FinnGen only)

Controls for this endpoint are individuals that are not cases.

Extra metadata

Level in the ICD hierarchy 3
First used in FinnGen datafreeze DF2
Parent code in ICD-10 D33
Name in latin Neoplasma benignum cerebri infratentoriale

Case counts by codes

FinnGen case counts by registry codes:

generic upset plot

Upset plot

Full data table

Summary Statistics

-FinRegistry-

Key figures

All Female Male
Number of individuals
Whole population 1554 828 719
Only index persons 1386 743 643
Unadjusted period prevalence (%)
Whole population 0.02 0.02 0.02
Only index persons 0.03 0.03 0.02
Median age at first event (years)
Whole population 44.15 46.77 40.95
Only index persons 43.19 45.75 40.23

-FinnGen-

Key figures

All Female Male
Number of individuals 178 107 71
Unadjusted period prevalence (%) 0.04 0.04 0.04
Median age at first event (years) 48.30 47.53 49.46

-FinRegistry-

Age distribution of first events

-FinnGen-

Age distribution of first events

-FinRegistry-

Year distribution of first events

-FinnGen-

Year distribution of first events

-FinRegistry-

Cumulative Incidence Function

-FinnGen-

Cumulative Incidence Function

No data

Mortality – FinRegistry

Association

Association between endpoint CD2_BENIGN_BRAIN_INFRATENT and mortality.

Females

Parameter HR [95% CI] p-value
CD2_BENIGN_BRAIN_INFRATENT 1.861 [1.47, 2.35] < 0.001
Birth year 0.994 [0.99, 1.0] 0.201

During the follow-up period (1.1.1998 — 31.12.2019), 125 out of 692 females with CD2_BENIGN_BRAIN_INFRATENT died.

Males

Parameter HR [95% CI] p-value
CD2_BENIGN_BRAIN_INFRATENT 2.417 [1.8, 3.24] < 0.001
Birth year 0.992 [0.98, 1.0] 0.089

During the follow-up period (1.1.1998 — 31.12.2019), 122 out of 603 males with CD2_BENIGN_BRAIN_INFRATENT died.

Mortality risk

Mortality risk for people of age

years, who have CD2_BENIGN_BRAIN_INFRATENT.

N-year risk Females Males
1 0.215% 0.496%
5 1.161% 3.052%
10 2.919% 7.476%
15 5.319% 14.591%
20 9.131% 24.239%

Relationships between endpoints

Index endpoint: CD2_BENIGN_BRAIN_INFRATENT – Benign neoplasm: Brain, infratentorial

GWS hits: -

Endpoint
Case Overlap
Survival Analysis
Genetic Correlations
Genetic Signals
N (Jaccard index)
HR [CI]
Extremity
rg [CI]
Extremity
Hits
Coloc Hits
FinRegistry
FinnGen
FinRegistry
FinnGen
FinnGen
loading spinner Loading data