No definition available.
Asthma and opportunity respiratory infection
EFO MESH Endpoint Browser PheWeb
ASTHMA_OPPORTUNIST_INFECTIONS
Endpoint definition
↥
Endpoint definition steps |
FinnGen |
|---|---|
Phenotype data |
473681 |
1. Apply sex-specific ruleNone |
473681 |
2. Check conditions
|
54128 |
3. Check pre-conditions, main-only, mode, registry filtersNone 0 out of 7 registries used, show all original rules. |
0 |
4. Check minimum number of eventsNone |
0 |
5. Include endpoints |
1440 |
6. Filter based on genotype QC (FinnGen only) |
1398 |
Control definitions (FinnGen only)
Control conditions
not J10_ASTHMA
Extra metadata
First used in FinnGen datafreeze
DF2
Similar endpoints
↥List of similar endpoints to
Asthma and opportunity respiratory infection
based on the number of shared cases.
Similar with more cases:
- Asthma
- Asthma
- Asthma, including avohilmo
- Chronic lower respiratory diseases
- COPD differential diagnosis
Similar with less cases:
None
Case counts by codes
↥FinnGen case counts by registry codes:
No data for upset plot.
No data for upset table.
Summary Statistics
↥-FinRegistry-
Key figures
| All | Female | Male | |
|---|---|---|---|
| Number of individuals | |||
| Whole population | 8980 | 5319 | 3578 |
| Only index persons | 7807 | 4794 | 3013 |
| Unadjusted period prevalence (%) | |||
| Whole population | 0.13 | 0.15 | 0.10 |
| Only index persons | 0.15 | 0.18 | 0.12 |
| Median age at first event (years) | |||
| Whole population | 63.65 | 63.39 | 64.10 |
| Only index persons | 63.61 | 63.28 | 64.15 |
-FinnGen-
Key figures
| All | Female | Male | |
|---|---|---|---|
| Number of individuals | 1398 | 854 | 544 |
| Unadjusted period prevalence (%) | 0.31 | 0.34 | 0.27 |
| Median age at first event (years) | 62.45 | 60.74 | 65.14 |
-FinRegistry-
Age distribution of first events
-FinnGen-
Age distribution of first events
-FinRegistry-
Year distribution of first events
-FinnGen-
Year distribution of first events
-FinRegistry-
Cumulative Incidence Function
-FinnGen-
Cumulative Incidence Function
Mortality – FinRegistry
↥Association
Association between endpoint ASTHMA_OPPORTUNIST_INFECTIONS and mortality.
Females
| Parameter | HR [95% CI] | p-value |
|---|---|---|
| ASTHMA_OPPORTUNIST_INFECTIONS | 1.696 [1.51, 1.91] | < 0.001 |
| Birth year | 0.994 [0.98, 1.01] | 0.305 |
During the follow-up period (1.1.1998 — 31.12.2019), 996 out of 3792 females with ASTHMA_OPPORTUNIST_INFECTIONS died.
Males
| Parameter | HR [95% CI] | p-value |
|---|---|---|
| ASTHMA_OPPORTUNIST_INFECTIONS | 1.784 [1.56, 2.04] | < 0.001 |
| Birth year | 0.989 [0.98, 1.0] | 0.026 |
During the follow-up period (1.1.1998 — 31.12.2019), 952 out of 2501 males with ASTHMA_OPPORTUNIST_INFECTIONS died.
Mortality risk
Mortality risk for people of age
years, who have ASTHMA_OPPORTUNIST_INFECTIONS.| N-year risk | Females | Males |
|---|---|---|
| 1 | 0.117% | 0.382% |
| 5 | 0.809% | 2.183% |
| 10 | 2.403% | 5.354% |
| 15 | 5.126% | 10.554% |
| 20 | 8.776% | 16.998% |
Relationships between endpoints
↥Index endpoint: ASTHMA_OPPORTUNIST_INFECTIONS – Asthma and opportunity respiratory infection
GWS hits: 1
Endpoint
Case Overlap
Survival Analysis
Genetic Correlations
Genetic Signals
N (Jaccard index)
HR [CI]
Extremity
rg [CI]
Extremity
Hits
Coloc Hits
FinRegistry
FinnGen
FinRegistry
FinnGen
FinnGen
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