aspergillosis: Aspergillosis is an infection, growth, or allergic response caused by the Aspergillus fungus. There are several different kinds of aspergillosis. One kind is allergic bronchopulmonary aspergillosis (also called ABPA), a condition where the fungus causes allergic respiratory symptoms similar to asthma, such as wheezing and coughing, but does not actually invade and destroy tissue. Another kind of aspergillosis is invasive aspergillosis. This infection usually affects people with weakened immune systems due to cancer, AIDS, leukemia, organ transplantation, chemotherapy, or other conditions or events that reduce the number of normal white blood cells. In this condition, the fungus invades and damages tissues in the body. Invasive aspergillosis most commonly affects the lungs, but can also cause infection in many other organs and can spread throughout the body (commonly affecting the kidneys and brain). Aspergilloma , a growth (fungus ball) that develops in an area of previous lung disease such as tuberculosis or lung abscess , is a third kind of aspergillosis. This type of aspergillosis is composed of a tangled mass of fungus fibers, blood clots, and white blood cells. The fungus ball gradually enlarges, destroying lung tissue in the process, but usually does not spread to other areas.
Endpoint definition
↥
Endpoint definition steps |
FinnGen |
---|---|
Phenotype data |
473681 |
1. Apply sex-specific ruleNone |
473681 |
2. Check conditionsNone |
473681 |
3. Check pre-conditions, main-only, mode, registry filtersRegistry filters: 2 out of 7 registries used, show all original rules. |
115 |
4. Check minimum number of eventsNone |
115 |
5. Include endpointsNone |
115 |
6. Filter based on genotype QC (FinnGen only) |
109 |
Control definitions (FinnGen only)
Extra metadata
Similar endpoints
↥List of similar endpoints to Allergic bronchopulmonary aspergillosis (ABPA) based on the number of shared cases.
Similar with more cases:
- Aspergillosis
- Mycoses
- Certain infectious and parasitic diseases
- Any operation in hilmo
- Any event in hilmo or specialist outpatient
Similar with less cases:
None
Case counts by codes
↥Summary Statistics
↥-FinRegistry-
Key figures
All | Female | Male | |
---|---|---|---|
Number of individuals | |||
Whole population | 699 | 250 | 439 |
Only index persons | 549 | 205 | 344 |
Unadjusted period prevalence (%) | |||
Whole population | 0.01 | 0.01 | 0.01 |
Only index persons | 0.01 | 0.01 | 0.01 |
Median age at first event (years) | |||
Whole population | 65.91 | 66.25 | 65.77 |
Only index persons | 65.36 | 65.64 | 65.20 |
-FinnGen-
Key figures
All | Female | Male | |
---|---|---|---|
Number of individuals | 109 | 41 | 68 |
Unadjusted period prevalence (%) | 0.03 | 0.02 | 0.03 |
Median age at first event (years) | 63.78 | 58.27 | 67.10 |
-FinRegistry-
Age distribution of first events
-FinnGen-
Age distribution of first events
-FinRegistry-
Year distribution of first events
-FinnGen-
Year distribution of first events
-FinRegistry-
Cumulative Incidence Function
-FinnGen-
Cumulative Incidence Function
Mortality – FinRegistry
↥Association
Association between endpoint ABPA and mortality.
Females
Parameter | HR [95% CI] | p-value |
---|---|---|
ABPA | 3.293 [2.26, 4.8] | < 0.001 |
Birth year | 0.998 [0.99, 1.01] | 0.603 |
During the follow-up period (1.1.1998 — 31.12.2019), 68 out of 184 females with ABPA died.
Males
Parameter | HR [95% CI] | p-value |
---|---|---|
ABPA | 4.575 [3.14, 6.67] | < 0.001 |
Birth year | 0.989 [0.98, 1.0] | 0.071 |
During the follow-up period (1.1.1998 — 31.12.2019), 146 out of 299 males with ABPA died.
Mortality risk
Mortality risk for people of age
years, who have ABPA.N-year risk | Females | Males |
---|---|---|
1 | 0.361% | 0.785% |
5 | 2.115% | 5.488% |
10 | 5.29% | 13.321% |
15 | 10.035% | 24.056% |
20 | 16.778% | 38.985% |
Relationships between endpoints
↥Index endpoint: ABPA – Allergic bronchopulmonary aspergillosis (ABPA)
GWS hits: -