Allergic bronchopulmonary aspergillosis (ABPA)

ABPA

aspergillosis: Aspergillosis is an infection, growth, or allergic response caused by the Aspergillus fungus. There are several different kinds of aspergillosis. One kind is allergic bronchopulmonary aspergillosis (also called ABPA), a condition where the fungus causes allergic respiratory symptoms similar to asthma, such as wheezing and coughing, but does not actually invade and destroy tissue. Another kind of aspergillosis is invasive aspergillosis. This infection usually affects people with weakened immune systems due to cancer, AIDS, leukemia, organ transplantation, chemotherapy, or other conditions or events that reduce the number of normal white blood cells. In this condition, the fungus invades and damages tissues in the body. Invasive aspergillosis most commonly affects the lungs, but can also cause infection in many other organs and can spread throughout the body (commonly affecting the kidneys and brain). Aspergilloma , a growth (fungus ball) that develops in an area of previous lung disease such as tuberculosis or lung abscess , is a third kind of aspergillosis. This type of aspergillosis is composed of a tangled mass of fungus fibers, blood clots, and white blood cells. The fungus ball gradually enlarges, destroying lung tissue in the process, but usually does not spread to other areas.

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Endpoint definition

Endpoint definition steps

FinnGen

Phenotype data

473681

1. Apply sex-specific rule

None

473681

2. Check conditions

None

473681

3. Check pre-conditions, main-only, mode, registry filters

Registry filters:

  • Hospital discharge: ICD-10 B44.1
  • Cause of death: ICD-10 B44.1

2 out of 7 registries used, show all original rules.

115

4. Check minimum number of events

None

115

5. Include endpoints

None

115

6. Filter based on genotype QC (FinnGen only)

109

Control definitions (FinnGen only)

Control exclude ASTHMA_COMORB

Extra metadata

First used in FinnGen datafreeze DF2
Parent code in ICD-10 B44
Name in latin Aspergillosis pulmonalis

Case counts by codes

FinnGen case counts by registry codes:

generic upset plot

Upset plot

Full data table

Summary Statistics

-FinRegistry-

Key figures

All Female Male
Number of individuals
Whole population 699 250 439
Only index persons 549 205 344
Unadjusted period prevalence (%)
Whole population 0.01 0.01 0.01
Only index persons 0.01 0.01 0.01
Median age at first event (years)
Whole population 65.91 66.25 65.77
Only index persons 65.36 65.64 65.20

-FinnGen-

Key figures

All Female Male
Number of individuals 109 41 68
Unadjusted period prevalence (%) 0.03 0.02 0.03
Median age at first event (years) 63.78 58.27 67.10

-FinRegistry-

Age distribution of first events

-FinnGen-

Age distribution of first events

-FinRegistry-

Year distribution of first events

-FinnGen-

Year distribution of first events

-FinRegistry-

Cumulative Incidence Function

-FinnGen-

Cumulative Incidence Function

No data

Mortality – FinRegistry

Association

Association between endpoint ABPA and mortality.

Females

Parameter HR [95% CI] p-value
ABPA 3.293 [2.26, 4.8] < 0.001
Birth year 0.998 [0.99, 1.01] 0.603

During the follow-up period (1.1.1998 — 31.12.2019), 68 out of 184 females with ABPA died.

Males

Parameter HR [95% CI] p-value
ABPA 4.575 [3.14, 6.67] < 0.001
Birth year 0.989 [0.98, 1.0] 0.071

During the follow-up period (1.1.1998 — 31.12.2019), 146 out of 299 males with ABPA died.

Mortality risk

Mortality risk for people of age

years, who have ABPA.

N-year risk Females Males
1 0.361% 0.785%
5 2.115% 5.488%
10 5.29% 13.321%
15 10.035% 24.056%
20 16.778% 38.985%

Relationships between endpoints

Index endpoint: ABPA – Allergic bronchopulmonary aspergillosis (ABPA)

GWS hits: -

Endpoint
Case Overlap
Survival Analysis
Genetic Correlations
Genetic Signals
N (Jaccard index)
HR [CI]
Extremity
rg [CI]
Extremity
Hits
Coloc Hits
FinRegistry
FinnGen
FinRegistry
FinnGen
FinnGen
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